FARP1

FARP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4H6Y
Identifiers
Aliases	FARP1, CDEP, FARP1-IT1, PLEKHC2, PPP1R75, FERM, ARH/RhoGEF and pleckstrin domain protein 1
External IDs	OMIM: 602654; MGI: 2446173; HomoloGene: 38098; GeneCards: FARP1; OMA:FARP1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	98,455,176 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	121,521,156 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; stromal cell of endometrium; ; corpus epididymis; ; ganglionic eminence; ; human kidney; ; ventricular zone; ; epithelium of colon; ; right lobe of liver; ; parotid gland; ; thyroid gland;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; mandibular prominence; ; molar; ; maxillary prominence; ; hand; ; Gonadal ridge; ; medullary collecting duct; ; vas deferens; ; pituitary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	guanyl-nucleotide exchange factor activity; cytoskeletal protein binding;
Cellular component	cytosol; cell projection; membrane; filopodium; extrinsic component of cytoplasmic side of plasma membrane; plasma membrane; dendritic spine; synapse; cell junction; dendrite; neuron projection; cytoskeleton; cytoplasm;
Biological process	dendrite morphogenesis; negative regulation of phosphatase activity; multicellular organism development; synapse assembly; regulation of Rho protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	10160
	223254
	ENSG00000152767
	ENSMUSG00000025555
	Q9Y4F1
	F8VPU2
	NM_001001715; NM_001286839; NM_005766
	NM_134082
	NP_001001715; NP_001273768; NP_005757
	NP_598843
	Wikidata
View/Edit Human	View/Edit Mouse

FERM, RhoGEF and pleckstrin domain-containing protein 1 is a protein that in humans is encoded by the FARP1 gene.

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.