FCN1

FCN1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D39, 2JHH, 2JHI, 2JHK, 2JHL, 2JHM, 2WNP
Identifiers
Aliases	FCN1, FCNM, ficolin 1
External IDs	OMIM: 601252; MGI: 1341158; HomoloGene: 1518; GeneCards: FCN1; OMA:FCN1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	134,917,912 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	27,974,897 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; trabecular bone; ; bone marrow; ; blood; ; bone marrow cells; ; buccal mucosa cell; ; appendix; ; spleen; ; periodontal fiber;
	Top expressed in
	granulocyte; ; morula; ; bone marrow; ; body of femur; ; lumbar subsegment of spinal cord; ; cochlea; ; vestibular membrane of cochlear duct; ; spleen; ; triceps brachii muscle; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sialic acid binding; protein binding; G protein-coupled receptor binding; metal ion binding; carbohydrate binding; pattern recognition receptor activity; serine-type endopeptidase activity; carbohydrate derivative binding;
Cellular component	extracellular region; plasma membrane; collagen; extrinsic component of external side of plasma membrane; membrane; secretory granule lumen; ficolin-1-rich granule lumen; collagen-containing extracellular matrix;
Biological process	complement activation, lectin pathway; complement activation; G protein-coupled receptor signaling pathway; recognition of apoptotic cell; protein localization to cell surface; cell surface pattern recognition receptor signaling pathway; immune system process; proteolysis; innate immune response; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
	2219
	14134
	ENSG00000085265
	ENSMUSG00000026835
	O00602
	O70497
	NM_002003
	NM_010190
	NP_001994
	NP_034320
	Wikidata
View/Edit Human	View/Edit Mouse

Ficolin-1, and also commonly termed M-ficolin is a protein that in humans is encoded by the FCN1 gene.

Proteins of the ficolin family consist of a leader peptide, a short N-terminal segment, followed by a collagen-like domain, and a C-terminal fibrinogen-like domain. The name of ficolin was derived from the latter two domains. The collagen-like and the fibrinogen-like domains are also found in other proteins such as tenascins, while the former is also found in complement protein C1q and collectins, which include mannose-binding lectin and lung surfactant proteins. Ficolins selectively recognize acetylated compounds. M-ficolin encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. Several SNPs have been described in the FCN1 gene with impact on serum concentrations of M-ficolin and the ligand binding ability. M-ficolin levels reflect disease activity and predict remission in early rheumatoid arthritis.