Free fatty acid receptor 3

FFAR3
Identifiers
Aliases	FFAR3, FFA3R, GPR41, GPR42, free fatty acid receptor 3
External IDs	OMIM: 603821; MGI: 2685324; HomoloGene: 82482; GeneCards: FFAR3; OMA:FFAR3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,360,489 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,555,603 bp
RNA expression pattern
	Top expressed in
	testicle; ; blood; ; islet of Langerhans; ; granulocyte; ; appendix; ; apex of heart; ; subcutaneous adipose tissue; ; monocyte; ; muscle layer of sigmoid colon; ; lactiferous gland;
	Top expressed in
	islet of Langerhans; ; embryo; ; blastocyst; ; nerve trunk; ; proximal tubule; ; autonomic nervous system; ; right kidney; ; sympathetic nervous system; ; sympathetic ganglion; ; duodenum;
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; lipid binding;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane;
Biological process	mucosal immune response; regulation of norepinephrine secretion; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; negative regulation of blood pressure; immune system process; positive regulation of cytokine production involved in immune response; regulation of hormone biosynthetic process; cellular response to fatty acid; positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of chemokine production; inflammatory response; regulation of peptide hormone secretion; signal transduction; G protein-coupled receptor signaling pathway; regulation of insulin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2865
	233080
	ENSG00000185897
	ENSMUSG00000019429
	O14843
	Q3UFD7
	NM_005304
	NM_001033316
	NP_005295
	NP_001028488
	Wikidata
View/Edit Human	View/Edit Mouse

Free fatty acid receptor 3 (FFAR3, also termed GPR41) protein is a G protein coupled receptor (i.e., GPR or GPCR) that in humans is encoded by the FFAR3 gene (i.e., GPR41 gene). GPRs reside on cell surfaces, bind specific signaling molecules, and thereby are activated to trigger certain functional responses in their parent cells. FFAR3 is a member of the free fatty acid receptor group of GPRs that includes FFAR1 (i.e., GPR40), FFAR2 (i.e., GPR43), and FFAR4 (i.e., GPR120). All of these FFARs are activated by fatty acids. FFAR3 and FFAR2 are activated by certain short-chain fatty acids (SC-FAs), i.e., fatty acids consisting of 2 to 6 carbon atoms whereas FFFAR1 and FFAR4 are activated by certain fatty acids that are 6 to more than 21 carbon atoms long. Hydroxycarboxylic acid receptor 2 is also activated by a SC-FA that activate FFAR3, i.e., butyric acid.