FLY (psychedelics)

FLY is a family of phenethylamine and benzofuran psychedelics possessing a benzodifuran or similar ring system. The FLY drugs were so-named because of the resemblance of their chemical structures to flying insects like dragonflies and butterflies. They are analogues of 2,5-dimethoxyphenethylamines in which the 2- and 5-position methoxy groups have been cyclized into furan and/or tetrahydrofuran rings. They may be 2C, DOx, 25-NB, or other FLY versions of psychedelic phenethylamines.

Examples of different types of FLY drugs, in the case of the base psychedelic 2C-B, include 2C-B-FLY, 2C-B-DRAGONFLY, 2C-B-BUTTERFLY, and 2C-B-MOTH. BromoDragonFLY (DOB-DragonFLY) is known for its very high potency and its toxicity in overdose. 2C-B-FLY was Ann Shulgin's favorite research chemical.

According to Alexander Shulgin, active doses or dose ranges of FLY drugs are 2.5 to 10 mg orally for 2C-B-FLY, 1 mg orally for DOB-FLY, and 100 μg intramuscularly for Bromo-DragonFLY (but it is also orally active). Other sources provide dose ranges of 0.2 to 0.8 mg orally for Bromo-DragonFLY, 1 mg orally for DOB-FLY, and 10 to 18 mg for 2C-B-FLY.

Several of the FLY drugs have been shown to act as potent serotonin 5-HT2 receptor agonists.

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