FADD

FADD
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3OQ9, 1A1W, 1A1Z, 1E3Y, 1E41, 2GF5, 3EZQ
Identifiers
Aliases	FADD, GIG3, MORT1, Fas associated via death domain, IMD90
External IDs	OMIM: 602457; MGI: 109324; HomoloGene: 2836; GeneCards: FADD; OMA:FADD - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	70,207,390 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; tendon of biceps brachii; ; stromal cell of endometrium; ; mucosa of transverse colon; ; blood; ; parotid gland; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; epithelium of esophagus;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	identical protein binding; tumor necrosis factor receptor superfamily binding; death effector domain binding; caspase binding; protein binding; protease binding; death receptor binding; tumor necrosis factor receptor binding; receptor serine/threonine kinase binding; protein-containing complex binding;
Cellular component	cytosol; membrane raft; ripoptosome; cell body; neuron projection; CD95 death-inducing signaling complex; plasma membrane; death-inducing signaling complex; cytoplasm; nucleus; protein-containing complex;
Biological process	TRAIL-activated apoptotic signaling pathway; regulation of extrinsic apoptotic signaling pathway via death domain receptors; motor neuron apoptotic process; immune system process; necroptotic signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of necroptotic process; positive regulation of interleukin-8 production; positive regulation of type I interferon-mediated signaling pathway; cell surface receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; positive regulation of macrophage differentiation; defense response to virus; activation of cysteine-type endopeptidase activity; apoptotic signaling pathway; cellular response to mechanical stimulus; extrinsic apoptotic signaling pathway in absence of ligand; positive regulation of transcription by RNA polymerase II; extrinsic apoptotic signaling pathway via death domain receptors; regulation of apoptotic process; death-inducing signaling complex assembly; positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of tumor necrosis factor production; positive regulation of I-kappaB kinase/NF-kappaB signaling; signal transduction; positive regulation of proteolysis; viral process; apoptotic process; positive regulation of activated T cell proliferation; extrinsic apoptotic signaling pathway; positive regulation of T cell mediated cytotoxicity; positive regulation of extrinsic apoptotic signaling pathway; thymus development; positive regulation of adaptive immune response; T cell differentiation in thymus; innate immune response; spleen development; negative regulation of activation-induced cell death of T cells; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of interferon-gamma production; positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation; lymph node development; T cell homeostasis; response to cocaine; response to morphine; behavioral response to cocaine; regulation of necroptotic process; positive regulation of apoptotic process; toll-like receptor 3 signaling pathway; kidney development;
	Sources:Amigo / QuickGO
Orthologs
	8772
	14082
	ENSG00000168040
	ENSMUSG00000031077
	Q13158
	Q61160
	NM_003824
	NM_010175
	NP_003815
	NP_034305
	Wikidata
View/Edit Human	View/Edit Mouse

FAS-associated death domain protein, also called MORT1, is encoded by the FADD gene on the 11q13.3 region of chromosome 11 in humans.

FADD is an adaptor protein that bridges members of the tumor necrosis factor receptor superfamily, such as the Fas-receptor, to procaspases 8 and 10 to form the death-inducing signaling complex (DISC) during apoptosis. As well as its most well known role in apoptosis, FADD has also been seen to play a role in other processes including proliferation, cell cycle regulation and development.