GPR182

GPR182
Identifiers
Aliases	GPR182, 7TMR, ADMR, AM-R, AMR, G10D, gamrh, hrhAMR, G protein-coupled receptor 182, L1-R
External IDs	OMIM: 605307; MGI: 109545; HomoloGene: 5255; GeneCards: GPR182; OMA:GPR182 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,998,447 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,587,601 bp
RNA expression pattern
	Top expressed in
	testicle; ; spleen; ; sperm; ; tendon of biceps brachii; ; left adrenal cortex; ; right adrenal cortex; ; tibialis anterior muscle; ; liver; ; right testis; ; left testis;
	Top expressed in
	yolk sac; ; atrium; ; mesenteric lymph nodes; ; right lung; ; liver; ; left lobe of liver; ; right lung lobe; ; endocardial cushion; ; left lung lobe; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; transmembrane signaling receptor activity; signal transducer activity;
Cellular component	plasma membrane; membrane; intracellular anatomical structure; integral component of membrane;
Biological process	G protein-coupled receptor signaling pathway; cell surface receptor signaling pathway; intracellular signal transduction; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	11318
	11536
	ENSG00000166856
	ENSMUSG00000058396
	O15218
	P43142
	NM_007264
	NM_007412
	NP_009195
	NP_031438
	Wikidata
View/Edit Human	View/Edit Mouse

GPR182 (or G protein-coupled receptor 182) is a human gene (and associated protein) which is an orphan G-protein coupled receptor.

When this gene was first cloned, it was proposed to encode an adrenomedullin receptor. However, when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM).

It was subsequently shown that a different GPCR, CALCRL when complexed with RAMP2 can function as an ADM receptor.