Gram domain containing 1b

GRAMD1B
Identifiers
Aliases	GRAMD1B, GRAM domain containing 1B, LINC01059, Aster-B
External IDs	MGI: 1925037; HomoloGene: 18223; GeneCards: GRAMD1B; OMA:GRAMD1B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	123,627,774 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	40,531,383 bp
RNA expression pattern
	Top expressed in
	left adrenal gland; ; right adrenal gland; ; paraflocculus of cerebellum; ; right adrenal cortex; ; left adrenal cortex; ; trigeminal ganglion; ; right hemisphere of cerebellum; ; lateral nuclear group of thalamus; ; spinal ganglia; ; parietal lobe;
	Top expressed in
	neural layer of retina; ; cerebellar cortex; ; yolk sac; ; decidua; ; adrenal medulla; ; visual cortex; ; superior frontal gyrus; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; lobe of cerebellum;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylserine binding; lipid binding; cholesterol binding; phosphatidic acid binding; cholesterol transfer activity;
Cellular component	membrane; integral component of membrane; endoplasmic reticulum; endoplasmic reticulum membrane; plasma membrane; endoplasmic reticulum-plasma membrane contact site;
Biological process	lipid transport; cholesterol transport; cholesterol homeostasis; cellular response to cholesterol; intermembrane sterol transfer;
	Sources:Amigo / QuickGO
Orthologs
	57476
	235283
	ENSG00000023171
	ENSMUSG00000040111
	Q3KR37
	Q80TI0
	NM_001286563; NM_001286564; NM_020716; NM_001330396
NM_172768; NM_001357617; NM_001357618; NM_001357619; NM_001357620;
	NM_001357621; NM_001357622; NM_001357623
NP_001273492; NP_001273493; NP_001317325; NP_065767; NP_001341766;
	NP_001354347; NP_001354348; NP_001354349; NP_001354350
NP_766356; NP_001344546; NP_001344547; NP_001344548; NP_001344549;
	NP_001344550; NP_001344551; NP_001344552
	Wikidata
View/Edit Human	View/Edit Mouse

GRAM domain containing 1B, also known as GRAMD1B, Aster-B and KIAA1201, is a cholesterol transport protein that is encoded by the GRAMD1B gene. It contains a transmembrane region and two domains of known function; the GRAM domain and a VASt domain. It is anchored to the endoplasmic reticulum. This highly conserved gene is found in a variety of vertebrates and invertebrates. Homologs (Lam/Ltc proteins) are found in yeast.