GRHPR

GRHPR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2GCG, 2H1S, 2Q50, 2WWR
Identifiers
Aliases	GRHPR, GLXR, GLYD, PH2, glyoxylate reductase/hydroxypyruvate reductase, glyoxylate and hydroxypyruvate reductase
External IDs	OMIM: 604296; MGI: 1923488; HomoloGene: 49088; GeneCards: GRHPR; OMA:GRHPR - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	37,436,990 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	44,990,734 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; left adrenal cortex; ; tendon of biceps brachii; ; human kidney; ; muscle of thigh; ; apex of heart; ; C1 segment;
	Top expressed in
	left lobe of liver; ; right kidney; ; proximal tubule; ; Ileal epithelium; ; human kidney; ; adrenal gland; ; yolk sac; ; cumulus cell; ; epithelium of stomach; ; brown adipose tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	glycerate dehydrogenase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; protein homodimerization activity; NAD binding; carboxylic acid binding; NADP binding; NADPH binding; oxidoreductase activity; hydroxypyruvate reductase activity; glyoxylate reductase (NADP+) activity;
Cellular component	cytoplasm; peroxisomal matrix; extracellular exosome; cytosol;
Biological process	dicarboxylic acid metabolic process; excretion; protein complex oligomerization; metabolism; cellular nitrogen compound metabolic process; glyoxylate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	9380
	76238
	ENSG00000137106
	ENSMUSG00000035637
	Q9UBQ7
	Q91Z53
	NM_012203
	NM_080289; NM_001312880
	NP_036335
	NP_001299809; NP_525028
	Wikidata
View/Edit Human	View/Edit Mouse

Glyoxylate reductase/hydroxypyruvate reductase is an enzyme that in humans is encoded by the GRHPR gene.

This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. GRHPR mutation analysis needs to pay attention to primer design, because allele dropout can cause false-positive result.