GRK5

GRK5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4TNB, 4TND
Identifiers
Aliases	GRK5, GPRK5, G protein-coupled receptor kinase 5, FP2025
External IDs	OMIM: 600870; MGI: 109161; HomoloGene: 3879; GeneCards: GRK5; OMA:GRK5 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	119,459,745 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	61,084,406 bp
RNA expression pattern
	Top expressed in
	saphenous vein; ; pylorus; ; synovial joint; ; cardia; ; lower lobe of lung; ; pericardium; ; jejunal mucosa; ; synovial membrane; ; urethra; ; right lung;
	Top expressed in
	blood; ; zygote; ; granulocyte; ; tail of embryo; ; secondary oocyte; ; Gonadal ridge; ; genital tubercle; ; myocardium of ventricle; ; esophagus; ; morula;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; G protein-coupled receptor kinase activity; kinase activity; protein serine/threonine kinase activity; protein binding; phospholipid binding; ATP binding; protein kinase C binding; lipid binding; beta-adrenergic receptor kinase activity;
Cellular component	nuclear membrane; membrane; plasma membrane; nucleus; cytoplasm; cytosol; nuclear speck;
Biological process	phosphorylation; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; negative regulation of apoptotic process; Wnt signaling pathway; tachykinin receptor signaling pathway; regulation of cell cycle; protein phosphorylation; positive regulation of cell population proliferation; protein autophosphorylation; fat cell differentiation; signal transduction; apoptotic process; regulation of G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2869
	14773
	ENSG00000198873
	ENSMUSG00000003228
	P34947
	Q8VEB1
	NM_005308
	NM_018869
	NP_005299
	NP_061357
	Wikidata
View/Edit Human	View/Edit Mouse

G protein-coupled receptor kinase 5 is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases, and is most highly similar to GRK4 and GRK6. The protein phosphorylates the activated forms of G protein-coupled receptors to regulate their signaling.