GRK6

GRK6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2ACX, 3NYN, 3NYO
Identifiers
Aliases	GRK6, GPRK6, G protein-coupled receptor kinase 6
External IDs	OMIM: 600869; MGI: 1347078; HomoloGene: 37570; GeneCards: GRK6; OMA:GRK6 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	177,442,901 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	55,608,740 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; monocyte; ; bone marrow cells; ; lymph node; ; spleen; ; appendix; ; beta cell; ; pancreatic ductal cell; ; male germ cell;
	Top expressed in
	mesenteric lymph nodes; ; Paneth cell; ; internal carotid artery; ; condyle; ; fossa; ; external carotid artery; ; granulocyte; ; Rostral migratory stream; ; blood; ; spleen;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; G protein-coupled receptor kinase activity; kinase activity; beta-adrenergic receptor kinase activity;
Cellular component	membrane; plasma membrane;
Biological process	protein phosphorylation; Wnt signaling pathway; phosphorylation; regulation of G protein-coupled receptor signaling pathway; signal transduction; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	2870
	26385
	ENSG00000198055
	ENSMUSG00000074886
	P43250
	O70293
	NM_001004105; NM_001004106; NM_002082; NM_001364164
NM_001038018; NM_001112711; NM_001286063; NM_001286064; NM_001286065;
	NM_001286066; NM_011938; NM_001377076; NM_001377077
	NP_001004105; NP_001004106; NP_002073; NP_001351093
NP_001033107; NP_001106182; NP_001272992; NP_001272993; NP_001272994;
	NP_001272995; NP_036068; NP_001364005; NP_001364006
	Wikidata
View/Edit Human	View/Edit Mouse

This gene encodes a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinase family, and is most highly similar to GRK4 and GRK5. The protein phosphorylates the activated forms of G protein-coupled receptors to regulate their signaling.