Metabotropic glutamate receptor 5

GRM5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LMK, 4OO9, 5CGC, 5CGD
Identifiers
Aliases	GRM5, GPRC1E, MGLUR5, PPP1R86, mGlu5, glutamate metabotropic receptor 5
External IDs	OMIM: 604102; MGI: 1351342; HomoloGene: 37354; GeneCards: GRM5; OMA:GRM5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	89,065,982 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	87,784,115 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; buccal mucosa cell; ; Brodmann area 10; ; Brodmann area 46; ; postcentral gyrus; ; orbitofrontal cortex; ; Brodmann area 23; ; superior frontal gyrus; ; Region I of hippocampus proper; ; frontal pole;
	Top expressed in
	lateral septal nucleus; ; olfactory tubercle; ; nucleus accumbens; ; subiculum; ; Amygdala; ; anterior amygdaloid area; ; lumbar subsegment of spinal cord; ; globus pallidus; ; subdivision of hippocampus; ; Region I of hippocampus proper;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glutamate receptor activity; G protein-coupled receptor activity; signal transducer activity; G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential; neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration; protein binding; protein tyrosine kinase activator activity; protein tyrosine kinase binding;
Cellular component	cytoplasm; integral component of membrane; neuron projection; plasma membrane; integral component of plasma membrane; extracellular exosome; postsynaptic density; membrane; presynaptic membrane; Schaffer collateral - CA1 synapse; postsynaptic density membrane;
Biological process	phospholipase C-activating G protein-coupled glutamate receptor signaling pathway; G protein-coupled glutamate receptor signaling pathway; G protein-coupled receptor signaling pathway; regulation of long-term neuronal synaptic plasticity; learning; cognition; locomotory behavior; signal transduction; chemical synaptic transmission; regulation of synaptic transmission, glutamatergic; adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway; regulation of postsynaptic membrane potential; regulation of postsynaptic cytosolic calcium ion concentration; regulation of protein phosphorylation; regulation of translation; regulation of translational elongation; learning or memory; calcium-mediated signaling using intracellular calcium source; synapse organization; positive regulation of protein tyrosine kinase activity; postsynaptic modulation of chemical synaptic transmission; trans-synaptic signaling by endocannabinoid, modulating synaptic transmission; regulation of intracellular calcium activated chloride channel activity; cellular response to amyloid-beta;
	Sources:Amigo / QuickGO
Orthologs
	2915
	108071
	ENSG00000168959
	ENSMUSG00000049583
	P41594
	Q3UVX5
	NM_000842; NM_001143831; NM_001384268
	NM_001033224; NM_001081414; NM_001143834
	NP_000833; NP_001137303
	NP_001074883; NP_001137306
	Wikidata
View/Edit Human	View/Edit Mouse

Metabotropic glutamate receptor 5 is an excitatory G_q-coupled G protein-coupled receptor predominantly expressed on the postsynaptic sites of neurons. In humans, it is encoded by the GRM5 gene.