Gq alpha subunit

guanine nucleotide binding protein (G protein), q polypeptide
Identifiers
SymbolGNAQ
NCBI gene2776
HGNC4390
OMIM600998
RefSeqNM_002072
UniProtP50148
Other data
LocusChr. 9 q21
Search for
StructuresSwiss-model
DomainsInterPro
guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Identifiers
SymbolGNA11
NCBI gene2767
HGNC4379
OMIM139313
RefSeqNM_002067
UniProtP29992
Other data
LocusChr. 19 p13.3
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StructuresSwiss-model
DomainsInterPro
guanine nucleotide binding protein (G protein), alpha 14
Identifiers
SymbolGNA14
NCBI gene9630
HGNC4382
OMIM604397
RefSeqNM_004297
UniProtO95837
Other data
LocusChr. 9 q21
Search for
StructuresSwiss-model
DomainsInterPro
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
Identifiers
SymbolGNA15
NCBI gene2769
HGNC4383
OMIM139314
RefSeqNM_002068
UniProtP30679
Other data
LocusChr. 19 p13.3
Search for
StructuresSwiss-model
DomainsInterPro

Gq protein alpha subunit is a family of heterotrimeric G protein alpha subunits. This family is also commonly called the Gq/11 (Gq/G11) family or Gq/11/14/15 family to include closely related family members. G alpha subunits may be referred to as Gq alpha, Gαq, or Gqα. Gq proteins couple to G protein-coupled receptors to activate beta-type phospholipase C (PLC-β) enzymes. PLC-β in turn hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol trisphosphate (IP3). IP3 acts as a second messenger to release stored calcium into the cytoplasm, while DAG acts as a second messenger that activates protein kinase C (PKC).

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