GSX2

GSX2
Identifiers
Aliases	GSX2, GSH2, GS homeobox 2, DMJDS2
External IDs	OMIM: 616253; MGI: 95843; HomoloGene: 15377; GeneCards: GSX2; OMA:GSX2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	54,102,498 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	75,238,554 bp
RNA expression pattern
	Top expressed in
	Amygdala; ; putamen; ; caudate nucleus; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; nucleus accumbens; ; C1 segment; ; tibial nerve; ; Brodmann area 9;
	Top expressed in
	urethra; ; female urethra; ; medial ganglionic eminence; ; male urethra; ; Rostral migratory stream; ; retinal pigment epithelium; ; superior frontal gyrus; ; ventricular zone; ; Mesencephalon; ; Thalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor activity;
Cellular component	nucleus;
Biological process	regulation of respiratory gaseous exchange by nervous system process; olfactory bulb interneuron differentiation; multicellular organism development; regulation of cell migration; telencephalon regionalization; central nervous system development; spinal cord association neuron differentiation; neuron fate commitment; regulation of transcription, DNA-templated; hindbrain morphogenesis; forebrain morphogenesis; subpallium neuron fate commitment; neuron fate specification; pattern specification process; positive regulation of oligodendrocyte differentiation; transcription, DNA-templated; positive regulation of Notch signaling pathway; forebrain dorsal/ventral pattern formation; brain development; subpallium development; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	170825
	14843
	ENSG00000180613
	ENSMUSG00000035946
	Q9BZM3
	P31316
	NM_133267
	NM_133256
	NP_573574
	NP_573555
	Wikidata
View/Edit Human	View/Edit Mouse

GS homeobox 2 (GSX2) is a protein encoded by a gene of the same name, located on chromosome 4 in humans, and on chromosome 5 in mice.

It is especially important to regulating the development of the brain, particularly during embryonic development. Mutations have been linked to a variety of neurological disorders that can cause intellectual disability, dystonia (difficulty with movement) and seizures.