Geranylgeranyltransferase type 1
| protein geranylgeranyltransferase type I | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.5.1.59 | ||||||||
| CAS no. | 135371-29-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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| GGTase 1 α-subunit (farnesyltransferase, CAAX box) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FNTA | ||||||
| NCBI gene | 2339 | ||||||
| HGNC | 3782 | ||||||
| OMIM | 134635 | ||||||
| PDB | 1S64 | ||||||
| RefSeq | NM_002027 | ||||||
| UniProt | P49354 | ||||||
| Other data | |||||||
| EC number | 2.5.1.59 | ||||||
| Locus | Chr. 8 p11.21 | ||||||
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| GGTase 1 β-subunit (protein geranylgeranyl- transferase type I, β subunit) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | PGGT1B | ||||||
| NCBI gene | 5229 | ||||||
| HGNC | 8895 | ||||||
| OMIM | 602031 | ||||||
| PDB | 1S64 | ||||||
| RefSeq | NM_005023 | ||||||
| UniProt | P53609 | ||||||
| Other data | |||||||
| EC number | 2.5.1.59 | ||||||
| Locus | Chr. 5 q23.1 | ||||||
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Geranylgeranyltransferase type 1 or simply geranylgeranyltransferase is one of the three enzymes in the prenyltransferase group. In specific terms, Geranylgeranyltransferase (GGTase 1) adds a 20-carbon isoprenoid called a geranylgeranyl group to proteins bearing a CaaX motif: a four-amino acid sequence at the carboxyl terminal of a protein. Geranylgeranyltransferase inhibitors are being investigated as anti-cancer agents.