Guanylate-binding protein
| Guanylate-binding protein, N-terminal domain | |||||||||
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structure of human guanylate binding protein-1 in nucleotide free form | |||||||||
| Identifiers | |||||||||
| Symbol | GBP | ||||||||
| Pfam | PF02263 | ||||||||
| Pfam clan | CL0023 | ||||||||
| InterPro | IPR015894 | ||||||||
| SCOP2 | 1dg3 / SCOPe / SUPFAM | ||||||||
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| Guanylate-binding protein, C-terminal domain | |||||||||
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Structure of human guanylate binding protein-1 in nucleotide free form | |||||||||
| Identifiers | |||||||||
| Symbol | GBP_C | ||||||||
| Pfam | PF02841 | ||||||||
| InterPro | IPR003191 | ||||||||
| SCOP2 | 1dg3 / SCOPe / SUPFAM | ||||||||
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In molecular biology, the guanylate-binding proteins family is a family of GTPases that is induced by interferon (IFN)-gamma. GTPases induced by IFN-gamma (Interferon-inducible GTPase) are key to the protective immunity against microbial and viral pathogens. These GTPases are classified into three groups: the small 47-KD immunity-related GTPases (IRGs), the Mx proteins (MX1, MX2), and the large 65- to 67-kd GTPases. Guanylate-binding proteins (GBP) fall into the last class.