H5N1 vaccine
| Vaccine description | |
|---|---|
| Target | H5N1 |
| Vaccine type | Inactivated |
| Clinical data | |
| Trade names | Audenz, others |
| AHFS/Drugs.com | Micromedex Detailed Consumer Information |
| License data | |
| ATC code | |
| Legal status | |
| Legal status | |
A H5N1 vaccine is an influenza vaccine intended to provide immunization to influenza A virus subtype H5N1.
Vaccination of poultry against the avian H5N1 influenza epizootic is widespread in certain countries. Some vaccines also exist for use in humans. As of July 2024, these include Aflunov, Audenz, Celldemic, and Incellipan.
The hemagglutinin protein is the main viral antigen of influenza A viruses, including the H5N1 subtype. Vaccination can induce antibodies that block the functions of the H5 hemagglutinin and neutralize virus infectivity.
The influenza virus is highly variable - the H5N1 virus infecting cattle in the USA is different from the viruses that showed up in poultry in 1997. However licensed vaccines can be updated in a process similar to that used for updating seasonal influenza vaccines.