Histidine ammonia-lyase

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histidine ammonia-lyase
histidine ammonia-lyase
	Histidine ammonia-lyase homotetramer, Pseudomonas putida
Identifiers
EC no.	4.3.1.3
CAS no.	9013-75-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
PMC
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PMC	articles
PubMed	articles
NCBI	proteins

HAL
Identifiers
Aliases	HAL, HIS, HSTD, histidine ammonia-lyase, Histidine ammonia-lyase
External IDs	OMIM: 609457; MGI: 96010; HomoloGene: 68229; GeneCards: HAL; OMA:HAL - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	95,996,365 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	93,355,166 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; human penis; ; skin of thigh; ; vulva; ; blood; ; oocyte; ; skin of arm; ; monocyte; ; secondary oocyte; ; skin of abdomen;
	Top expressed in
	morula; ; skin of external ear; ; left lobe of liver; ; lip; ; skin of back; ; lumbar spinal ganglion; ; calvaria; ; umbilical cord; ; spermatid; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	catalytic activity; lyase activity; ammonia-lyase activity; histidine ammonia-lyase activity;
Cellular component	cytosol; cytoplasm;
Biological process	histidine metabolic process; histidine catabolic process to glutamate and formate; histidine catabolic process to glutamate and formamide; histidine catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3034
	15109
	ENSG00000084110
	ENSMUSG00000020017
	P42357
	P35492
	NM_001258333; NM_001258334; NM_002108
	NM_010401
	NP_001245262; NP_001245263; NP_002099
	NP_034531
	Wikidata
View/Edit Human	View/Edit Mouse

Histidine ammonia-lyase (EC 4.3.1.3, histidase, histidinase) is an enzyme that in humans is encoded by the HAL gene. It converts histidine into ammonia and urocanic acid. Its systematic name is L-histidine ammonia-lyase (urocanate-forming).