Heparin-binding EGF-like growth factor

HBEGF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1XDT, 2M8S
Identifiers
Aliases	HBEGF, DTR, DTS, DTSF, HEGFL, heparin binding EGF like growth factor
External IDs	OMIM: 126150; MGI: 96070; HomoloGene: 1466; GeneCards: HBEGF; OMA:HBEGF - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,346,603 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,648,858 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; gallbladder; ; mucosa of urinary bladder; ; lower lobe of lung; ; synovial membrane; ; upper lobe of left lung; ; Skeletal muscle tissue of rectus abdominis; ; pericardium; ; skin of thigh; ; apex of heart;
	Top expressed in
	ankle; ; ankle joint; ; decidua; ; muscle of thigh; ; sciatic nerve; ; triceps brachii muscle; ; endothelial cell of lymphatic vessel; ; lumbar subsegment of spinal cord; ; epithelium of lens; ; right lung;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	growth factor activity; heparin binding; protein tyrosine kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; epidermal growth factor receptor binding;
Cellular component	extracellular region; endocytic vesicle membrane; integral component of membrane; membrane; cell surface; plasma membrane; clathrin-coated endocytic vesicle membrane; integral component of plasma membrane; extracellular space; clathrin-coated vesicle membrane;
Biological process	positive regulation of keratinocyte migration; cell chemotaxis; MAPK cascade; signal transduction; wound healing, spreading of epidermal cells; positive regulation of cell migration; positive regulation of cell growth; muscle organ development; positive regulation of smooth muscle cell proliferation; regulation of heart contraction; negative regulation of elastin biosynthetic process; cell migration; positive regulation of wound healing; epidermal growth factor receptor signaling pathway; ERBB2 signaling pathway; phosphatidylinositol phosphate biosynthetic process; peptidyl-tyrosine phosphorylation; regulation of cell motility; positive regulation of cell population proliferation; positive regulation of peptidyl-tyrosine phosphorylation; regulation of signaling receptor activity; positive regulation of protein kinase B signaling; negative regulation of epidermal growth factor receptor signaling pathway; membrane organization;
	Sources:Amigo / QuickGO
Orthologs
	1839
	15200
	ENSG00000113070
	ENSMUSG00000024486
	Q99075
	Q06186
	NM_001945
	NM_010415
	NP_001936
	NP_034545
	Wikidata
View/Edit Human	View/Edit Mouse

Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene.

HB-EGF-like growth factor is synthesized as a membrane-anchored mitogenic and chemotactic glycoprotein. An epidermal growth factor produced by monocytes and macrophages, due to an affinity for heparin is termed HB-EGF. It has been shown to play a role in wound healing, cardiac hypertrophy, and heart development and function. First identified in the conditioned media of human macrophage-like cells, HB-EGF is an 87-amino acid glycoprotein that displays highly regulated gene expression. Ectodomain shedding results in the soluble mature form of HB-EGF, which influences the mitogenicity and chemotactic factors for smooth muscle cells and fibroblasts. The transmembrane form of HB-EGF is the unique receptor for diphtheria toxin and functions in juxtacrine signaling in cells. Both forms of HB-EGF participate in normal physiological processes and in pathological processes including tumor progression and metastasis, organ hyperplasia, and atherosclerotic disease. HB-EGF can bind two locations on cell surfaces: heparan sulfate proteoglycans and EGF-receptors effecting cell-to-cell interactions.