HEAT repeat

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1b3u, 1f59, 1gcj, 1ibr, 1m5n, 1o6o, 1o6p, 1qbk, 1qgr, 1u6g, 1ukl, 2bku

HEAT repeat
HEAT repeat
	An example of an alpha solenoid structure composed of 15 HEAT repeats. The protein phosphatase 2A regulatory subunit is shown with the N-terminus in blue at bottom and the C-terminus in red at top. A single helix-turn-helix motif is shown in the center with the outer helix in pink, the inner helix in green, and the turn in white. From PDB: 2IAE.
Identifiers
Symbol	HEAT
Pfam	PF02985
InterPro	IPR000357
PROSITE	PDOC50077
SCOP2	1b3u / SCOPe / SUPFAM
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary
PDB	1b3u, 1f59, 1gcj, 1ibr, 1m5n, 1o6o, 1o6p, 1qbk, 1qgr, 1u6g, 1ukl, 2bku

A HEAT repeat is a protein tandem repeat structural motif composed of two alpha helices linked by a short loop. HEAT repeats can form alpha solenoids, a type of solenoid protein domain found in a number of cytoplasmic proteins. The name "HEAT" is an acronym for four proteins in which this repeat structure is found: Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1. HEAT repeats form extended superhelical structures which are often involved in intracellular transport; they are structurally related to armadillo repeats. The nuclear transport protein importin beta contains 19 HEAT repeats.