Protein phosphatase 2

protein phosphatase 2, catalytic subunit, alpha isoform
The catalytic (C) subunit of protein phosphatase 2A. The protein is shown in rainbow color with the N-terminus in blue and the C-terminus in red. The methylated carboxyl group of the C-terminal leucine residue is shown in white. The purple spheres are two catalytically required manganese ions and the dark gray compound at center is a peptidomimetic toxin, microcystin, occupying the active site. From PDB: 2IAE​.
Identifiers
SymbolPPP2CA
NCBI gene5515
HGNC9299
OMIM176915
RefSeqNM_002715
UniProtP67775
Other data
EC number3.1.3.16
LocusChr. 5 q23-q31
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StructuresSwiss-model
DomainsInterPro
protein phosphatase 2, catalytic subunit, beta isoform
Identifiers
SymbolPPP2CB
NCBI gene5516
HGNC9300
OMIM176916
RefSeqNM_001009552
UniProtP62714
Other data
EC number3.1.3.16
LocusChr. 8 p12
Search for
StructuresSwiss-model
DomainsInterPro

Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. Its serine/threonine phosphatase activity has a broad substrate specificity and diverse cellular functions. Among the targets of PP2A are proteins of oncogenic signaling cascades, such as Raf, MEK, and AKT, where PP2A may act as a tumor suppressor.

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