HIPK2

HIPK2
Identifiers
Aliases	HIPK2, PRO0593, homeodomain interacting protein kinase 2
External IDs	OMIM: 606868; MGI: 1314872; HomoloGene: 68766; GeneCards: HIPK2; OMA:HIPK2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	139,777,998 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	38,853,099 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; inferior ganglion of vagus nerve; ; ventral tegmental area; ; subthalamic nucleus; ; external globus pallidus; ; superior vestibular nucleus; ; pars reticulata; ; renal medulla; ; pars compacta; ; Pons;
	Top expressed in
	vestibular membrane of cochlear duct; ; genital tubercle; ; Rostral migratory stream; ; tail of embryo; ; lumbar subsegment of spinal cord; ; knee joint; ; right ventricle; ; secondary oocyte; ; triceps brachii muscle; ; deep cerebellar nuclei;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; transcription coactivator activity; SMAD binding; transferase activity; kinase activity; virion binding; ATP binding; protein binding; protein kinase activity; transcription corepressor activity; protein serine/threonine kinase activity;
Cellular component	cytoplasm; PML body; RNA polymerase II transcription regulator complex; nuclear body; nucleus; nucleoplasm;
Biological process	anterior/posterior pattern specification; smoothened signaling pathway; regulation of cell cycle; transforming growth factor beta receptor signaling pathway; positive regulation of DNA binding; intrinsic apoptotic signaling pathway; transcription, DNA-templated; lens induction in camera-type eye; peptidyl-serine phosphorylation; embryonic camera-type eye morphogenesis; peptidyl-threonine phosphorylation; eye development; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of DNA-binding transcription factor activity; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; voluntary musculoskeletal movement; SMAD protein signal transduction; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; adult walking behavior; apoptotic process; adult locomotory behavior; protein phosphorylation; negative regulation of transcription by RNA polymerase II; iris morphogenesis; positive regulation of cell population proliferation; positive regulation of transcription, DNA-templated; cellular response to DNA damage stimulus; positive regulation of JNK cascade; PML body organization; negative regulation of neuron apoptotic process; positive regulation of angiogenesis; regulation of transcription, DNA-templated; embryonic retina morphogenesis in camera-type eye; modulation by virus of host process; retina layer formation; positive regulation of transcription by RNA polymerase II; neuron differentiation; positive regulation of protein binding; cellular response to hypoxia; positive regulation of protein phosphorylation; erythrocyte differentiation; negative regulation of BMP signaling pathway; phosphorylation; regulation of signal transduction by p53 class mediator; transcription by RNA polymerase II; negative regulation of ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	28996
	15258
	ENSG00000064393
	ENSMUSG00000061436
	Q9H2X6
	Q9QZR5
	NM_001113239; NM_022740
	NM_001136065; NM_001294143; NM_001294144; NM_010433
	NP_001106710; NP_073577
	NP_001129537; NP_001281072; NP_001281073; NP_034563
	Wikidata
View/Edit Human	View/Edit Mouse

Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene. HIPK2 can be categorized as a Serine/Threonine Protein kinase, specifically one that interacts with homeodomain transcription factors. It belongs to a family of protein kinases known as the DYRK kinases. Within this family HIPK2 belongs to a group of homeodomain-interacting protein kinases (HIPKs), including HIPK1 and HIPK3. HIPK2 can be found in a wide variety of species and its functions in gene expression and apoptosis are regulated by several different mechanisms.