HS3ST3B1

HS3ST3B1
Identifiers
Aliases	HS3ST3B1, 30ST3B1, 3OST3B1, 3-OST-3B, h3-OST-3B, heparan sulfate-glucosamine 3-sulfotransferase 3B1
External IDs	OMIM: 604058; MGI: 1333853; HomoloGene: 88576; GeneCards: HS3ST3B1; OMA:HS3ST3B1 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	14,349,404 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	63,813,116 bp
RNA expression pattern
	Top expressed in
	tibia; ; parotid gland; ; epithelium of nasopharynx; ; right lobe of liver; ; palpebral conjunctiva; ; placenta; ; cartilage tissue; ; gingival epithelium; ; germinal epithelium; ; stromal cell of endometrium;
	Top expressed in
	epithelium of stomach; ; left lobe of liver; ; renal corpuscle; ; female external genitalia; ; paramesonephric duct; ; retinal pigment epithelium; ; ciliary body; ; neural layer of retina; ; cornea; ; abdominal wall;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; sulfotransferase activity; [heparan sulfate-glucosamine 3-sulfotransferase 3 activity]; [heparan sulfate-glucosamine 3-sulfotransferase 1 activity]; heparan sulfate sulfotransferase activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; integral component of plasma membrane; membrane;
Biological process	heparan sulfate proteoglycan biosynthetic process; heparan sulfate proteoglycan biosynthetic process, enzymatic modification; glycosaminoglycan biosynthetic process; protein sulfation;
	Sources:Amigo / QuickGO
Orthologs
	9953
	54710
	ENSG00000125430
	ENSMUSG00000070407
	Q9Y662
	Q9QZS6
	NM_006041
	NM_018805
	NP_006032
	NP_061275
	Wikidata
View/Edit Human	View/Edit Mouse

Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 is an enzyme that in humans is encoded by the HS3ST3B1 gene. Heparan sulfate biosynthetic enzymes are key components in generating myriad distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity ( HS3ST3A1). The Sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1 and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta.