HSPA1L

HSPA1L
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3GDQ
Identifiers
Aliases	HSPA1L, HSP70-1L, HSP70-HOM, HSP70T, hum70t, heat shock protein family A (Hsp70) member 1 like
External IDs	OMIM: 140559; MGI: 96231; HomoloGene: 135835; GeneCards: HSPA1L; OMA:HSPA1L - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	31,815,283 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,198,261 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; testicle; ; muscle of thigh; ; skeletal muscle tissue; ; gonad; ; blood; ; granulocyte; ; gastrocnemius muscle; ; ganglionic eminence;
	Top expressed in
	seminiferous tubule; ; spermatid; ; soleus muscle; ; muscle of thigh; ; spermatocyte; ; tibialis anterior muscle; ; intercostal muscle; ; plantaris muscle; ; temporal muscle; ; sternocleidomastoid muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding; nucleotide binding; protein binding; ATP binding; heat shock protein binding; ubiquitin protein ligase binding; ATPase activity; protein folding chaperone activity; misfolded protein binding;
Cellular component	COP9 signalosome; cytosol; mitochondrial matrix; blood microparticle; mitochondrion; nucleoplasm; zona pellucida receptor complex; cell body; cytoplasm;
Biological process	regulation of cellular response to heat; response to unfolded protein; protein refolding; positive regulation of protein targeting to mitochondrion; binding of sperm to zona pellucida; cellular response to heat; Unfolded Protein Response; chaperone cofactor-dependent protein refolding;
	Sources:Amigo / QuickGO
Orthologs
	3305
	15482
ENSG00000234258; ENSG00000226704; ENSG00000236251; ENSG00000204390; ENSG00000206383;
	n/a
	ENSMUSG00000007033
	P34931
	P16627
	NM_005527
	NM_013558
	NP_005518
	NP_038586
	Wikidata
View/Edit Human	View/Edit Mouse

Heat shock 70 kDa protein 1L is a protein that in humans is encoded by the HSPA1L gene on chromosome 6. As a member of the heat shock protein 70 (Hsp70) family and a chaperone protein, it facilitates the proper folding of newly translated and misfolded proteins, as well as stabilize or degrade mutant proteins. Its functions contribute to biological processes including signal transduction, apoptosis, protein homeostasis, and cell growth and differentiation. It has been associated with an extensive number of cancers, neurodegenerative diseases, cell senescence and aging, and Graft-versus-host disease.