Interleukin 33

IL33
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2KLL, 4KC3
Identifiers
Aliases	IL33, C9orf26, DVS27, IL1F11, NF-HEV, NFEHEV, Interleukin 33, IL-33, IL-1F11
External IDs	OMIM: 608678; MGI: 1924375; HomoloGene: 14126; GeneCards: IL33; OMA:IL33 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	6,257,983 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	29,938,118 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; right coronary artery; ; olfactory zone of nasal mucosa; ; smooth muscle tissue; ; left coronary artery; ; Descending thoracic aorta; ; gallbladder; ; lymph node; ; ascending aorta; ; right auricle of heart;
	Top expressed in
	ciliary body; ; olfactory epithelium; ; sciatic nerve; ; renal capsule; ; iris; ; mucous cell of stomach; ; substantia nigra; ; epithelium of stomach; ; endolymphatic duct; ; esophagus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; protein binding;
Cellular component	transport vesicle; chromosome; cytoplasmic vesicle; nucleus; extracellular region; extracellular space; nucleoplasm;
Biological process	negative regulation of interferon-gamma production; positive regulation of inflammatory response; positive regulation of interleukin-5 production; extrinsic apoptotic signaling pathway; positive regulation of macrophage activation; negative regulation of T-helper 1 type immune response; positive regulation of interleukin-4 production; transcription, DNA-templated; positive regulation of interleukin-13 production; positive regulation of gene expression; defense response to virus; positive regulation of interleukin-6 production; positive regulation of type 2 immune response; negative regulation of leukocyte migration; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of transcription by RNA polymerase II; microglial cell proliferation; macrophage activation involved in immune response; microglial cell activation involved in immune response; type 2 immune response; protein deubiquitination; regulation of signaling receptor activity; interleukin-33-mediated signaling pathway; positive regulation of neuroinflammatory response;
	Sources:Amigo / QuickGO
Orthologs
	90865
	77125
	ENSG00000137033
	ENSMUSG00000024810
	O95760
	Q8BVZ5
NM_001199640; NM_001199641; NM_001314044; NM_001314045; NM_001314046;
	NM_001314047; NM_001314048; NM_033439; NM_001353802
	NM_001164724; NM_133775; NM_001360725
NP_001186569; NP_001186570; NP_001300973; NP_001300974; NP_001300975;
	NP_001300976; NP_001300977; NP_254274; NP_001340731
	NP_001158196; NP_598536; NP_001347654
	Wikidata
View/Edit Human	View/Edit Mouse

Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene.

Interleukin 33 is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL-4). IL33 is a ligand for ST2 (IL1RL1), an IL-1 family receptor that is highly expressed on Th2 cells, mast cells and group 2 innate lymphocytes.

IL-33 is expressed by a wide variety of cell types, including fibroblasts, mast cells, dendritic cells, macrophages, osteoblasts, endothelial cells, and epithelial cells.