IMP-1088

IMP-1088
Identifiers
	IUPAC name 1-(5-{3,4-Difluoro-2-[2-(1,3,5-trimethyl-1''H''-pyrazol-4-yl)ethoxy]phenyl}-1-methyl-1''H''-indazol-3-yl)-''N'',''N''-dimethylmethanamine;
CAS Number	2059148-82-0;
PubChem CID	132274735;
ChemSpider	65326081;
UNII	ZT62NQ6YEV;
ChEMBL	ChEMBL4445137;
PDB ligand	KFK (PDBe, RCSB PDB);
CompTox Dashboard (EPA)	DTXSID301336328 ;
Chemical and physical data
Formula	C25H29F2N5O
Molar mass	453.538 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC1=C(C(=NN1C)C)CCOC2=C(C=CC(=C2F)F)C3=CC4=C(C=C3)N(N=C4CN(C)C)C;
	InChI InChI=InChI=1S/C25H29F2N5O/c1-15-18(16(2)31(5)28-15)11-12-33-25-19(8-9-21(26)24(25)27)17-7-10-23-20(13-17)22(14-30(3)4)29-32(23)6/h7-10,13H,11-12,14H2,1-6H3; Key:SOXNKJCQBRQUMS-UHFFFAOYSA-N;

IMP-1088 is an enzyme inhibitor of the human N-myristoyltransferases NMT1 and NMT2. It prevents the production of infectious virus particles by targeting host cell machinery rather than the virus itself. Specifically, it inhibits the host's NMT enzymes, blocking the myristoylation of viral proteins required for capsid assembly. Since this strategy acts on host proteins, it is thought to carry a lower risk of viral resistance.

Identifiers

IUPAC name 1-(5-{3,4-Difluoro-2-[2-(1,3,5-trimethyl-1''H''-pyrazol-4-yl)ethoxy]phenyl}-1-methyl-1''H''-indazol-3-yl)-''N'',''N''-dimethylmethanamine
CAS Number	2059148-82-0
PubChem CID	132274735
ChemSpider	65326081
UNII	ZT62NQ6YEV
ChEMBL	ChEMBL4445137
PDB ligand	KFK (PDBe, RCSB PDB)
CompTox Dashboard (EPA)	DTXSID301336328
Chemical and physical data
Formula	C₂₅H₂₉F₂N₅O
Molar mass	453.538 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=C(C(=NN1C)C)CCOC2=C(C=CC(=C2F)F)C3=CC4=C(C=C3)N(N=C4CN(C)C)C
InChI InChI=InChI=1S/C25H29F2N5O/c1-15-18(16(2)31(5)28-15)11-12-33-25-19(8-9-21(26)24(25)27)17-7-10-23-20(13-17)22(14-30(3)4)29-32(23)6/h7-10,13H,11-12,14H2,1-6H3 Key:SOXNKJCQBRQUMS-UHFFFAOYSA-N