IPO5

IPO5
Identifiers
Aliases	IPO5, IMB3, KPNB3, Pse1, RANBP5, imp5, importin 5
External IDs	OMIM: 602008; MGI: 1917822; HomoloGene: 1710; GeneCards: IPO5; OMA:IPO5 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	98,024,296 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	121,185,411 bp
RNA expression pattern
	Top expressed in
	sperm; ; left testis; ; right testis; ; ventricular zone; ; embryo; ; cartilage tissue; ; ganglionic eminence; ; body of pancreas; ; gastrocnemius muscle; ; stromal cell of endometrium;
	Top expressed in
	seminiferous tubule; ; primitive streak; ; epiblast; ; somite; ; lens; ; tail of embryo; ; spermatid; ; medullary collecting duct; ; ventricular zone; ; mandibular prominence;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	GTPase inhibitor activity; protein binding; nuclear localization sequence binding; RNA binding; nuclear import signal receptor activity;
Cellular component	membrane; nuclear periphery; nuclear pore; nucleolus; nucleus; nuclear membrane; cytoplasm;
Biological process	ribosomal protein import into nucleus; cellular response to amino acid stimulus; protein transport; positive regulation of protein import into nucleus; viral process; intracellular protein transport; negative regulation of GTPase activity; NLS-bearing protein import into nucleus; transport; protein import into nucleus; negative regulation of cyclin-dependent protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	3843
	70572
	ENSG00000065150
	ENSMUSG00000030662
	O00410
	Q8BKC5
	NM_002271
	NM_023579; NM_001360602
	NP_002262
	NP_076068; NP_001347531
	Wikidata
View/Edit Human	View/Edit Mouse

Importin-5 is a protein that in humans is encoded by the IPO5 gene. The protein encoded by this gene is a member of the importin beta family. Structurally, the protein adopts the shape of a right hand solenoid and is composed of 24 HEAT repeats.