IRAK4

IRAK4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2NRU, 2NRY, 2O8Y, 2OIB, 2OIC, 2OID, 3MOP, 4U97, 4U9A, 4XS2, 4Y73, 4YO6, 4YP8, 4ZTL, 4ZTM, 4ZTN, 4RMZ
Identifiers
Aliases	IRAK4, IPD1, IRAK-4, NY-REN-64, REN64, interleukin 1 receptor associated kinase 4, IMD67
External IDs	OMIM: 606883; MGI: 2182474; HomoloGene: 41109; GeneCards: IRAK4; OMA:IRAK4 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	43,798,307 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	94,479,696 bp
RNA expression pattern
	Top expressed in
	monocyte; ; body of pancreas; ; granulocyte; ; rectum; ; gallbladder; ; lymph node; ; blood; ; Achilles tendon; ; spleen; ; appendix;
	Top expressed in
	granulocyte; ; jejunum; ; tibiofemoral joint; ; duodenum; ; conjunctival fornix; ; stroma of bone marrow; ; yolk sac; ; intestinal villus; ; blood; ; lumbar subsegment of spinal cord;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; protein kinase activity; magnesium ion binding; transferase activity; interleukin-1 receptor binding; kinase activity; ATP binding; protein binding; protein serine/threonine kinase activity;
Cellular component	endosome membrane; cytoplasm; cytosol; nucleus; plasma membrane; extracellular space; intracellular anatomical structure;
Biological process	JNK cascade; signal transduction; toll-like receptor 9 signaling pathway; neutrophil migration; toll-like receptor signaling pathway; protein phosphorylation; positive regulation of smooth muscle cell proliferation; neutrophil mediated immunity; MyD88-dependent toll-like receptor signaling pathway; cytokine-mediated signaling pathway; innate immune response; positive regulation of I-kappaB kinase/NF-kappaB signaling; cytokine production; immune system process; phosphorylation; positive regulation of NF-kappaB transcription factor activity; interleukin-1-mediated signaling pathway; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	51135
	266632
	ENSG00000198001
	ENSMUSG00000059883
	Q9NWZ3; Q69FE3
	Q8R4K2
NM_001114182; NM_001145256; NM_001145257; NM_001145258; NM_016123;
	NM_001351338; NM_001351339; NM_001351340; NM_001351341; NM_001351342; NM_001351343; NM_001351344; NM_001351345
	NM_029926
NP_001107654; NP_001138728; NP_001138729; NP_001138730; NP_057207;
	NP_001338267; NP_001338268; NP_001338269; NP_001338270; NP_001338271; NP_001338272; NP_001338273; NP_001338274; NP_001107654.1; NP_057207.2
	NP_084202
	Wikidata
View/Edit Human	View/Edit Mouse

IRAK-4 (interleukin-1 receptor-associated kinase 4), in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. IRAK4 contains domain structures which are similar to those of IRAK1, IRAK2, IRAK3 and Pelle. IRAK4 is unique compared to IRAK1, IRAK2 and IRAKM in that it functions upstream of the other IRAKs, but is more similar to Pelle in this trait. IRAK4 has important clinical applications.

Animals without IRAK-4 are more susceptible to viruses and bacteria but completely resistant to LPS challenge.