ISG15

ISG15
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z2M, 2HJ8, 3PHX, 3PSE, 3R66, 3RT3, 3SDL
Identifiers
Aliases	ISG15, G1P2, IFI15, IP17, UCRP, hUCRP, IMD38, ISG15 ubiquitin-like modifier, ISG15 ubiquitin like modifier
External IDs	OMIM: 147571; MGI: 1855694; HomoloGene: 48326; GeneCards: ISG15; OMA:ISG15 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,014,540 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	156,285,253 bp
RNA expression pattern
	Top expressed in
	decidua; ; periodontal fiber; ; testicle; ; granulocyte; ; amniotic fluid; ; lateral nuclear group of thalamus; ; trigeminal ganglion; ; stromal cell of endometrium; ; monocyte; ; Amygdala;
	Top expressed in
	bone marrow; ; jejunum; ; granulocyte; ; placenta; ; colon; ; thymus; ; spleen; ; duodenum; ; ileum; ; esophagus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; protein tag; integrin binding;
Cellular component	cytoplasm; cytosol; nucleoplasm; extracellular region;
Biological process	immune system process; regulation of interferon-gamma production; negative regulation of protein ubiquitination; negative regulation of viral genome replication; defense response to virus; type I interferon signaling pathway; response to type I interferon; translesion synthesis; negative regulation of type I interferon production; viral process; innate immune response; modification-dependent protein catabolic process; positive regulation of bone mineralization; ISG15-protein conjugation; defense response to bacterium; positive regulation of erythrocyte differentiation; response to bacterium; integrin-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9636
	100038882
	ENSG00000187608
	ENSMUSG00000035692
	P05161
	Q64339
	NM_005101
	NM_015783
	NP_005092
	NP_056598
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-stimulated gene 15 (ISG15) is a 17 kDa secreted protein that in humans is encoded by the ISG15 gene. ISG15 is induced by type I interferon (IFN) and serves many functions, acting both as an extracellular cytokine and an intracellular protein modifier. The precise functions are diverse and vary among species but include potentiation of Interferon gamma (IFN-II) production in lymphocytes, ubiquitin-like conjugation to newly-synthesized proteins and negative regulation of the IFN-I response.