Kir6.2

KCNJ11

Identifiers

KCNJ11, BIR, HHF2, IKATP, KIR6.2, MODY13, PHHI, TNDM3, potassium voltage-gated channel subfamily J member 11, potassium inwardly rectifying channel subfamily J member 11, PNDM2

External IDs

OMIM: 600937; MGI: 107501; HomoloGene: 441; GeneCards: KCNJ11; OMA:KCNJ11 - orthologs

Gene location (Human)

Chr.	Chromosome 11 (human)

Band	11p15.1	Start	17,365,172 bp
Band	11p15.1	End	17,389,331 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	7 B3\|7 29.66 cM	Start	45,743,377 bp
Band	7 B3\|7 29.66 cM	End	45,750,188 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

gastrocnemius muscle

muscle of thigh

tibialis anterior muscle

right hemisphere of cerebellum

apex of heart

islet of Langerhans

right frontal lobe

prefrontal cortex

left ventricle

skeletal muscle tissue

Top expressed in

gastrula

muscle of thigh

medial ganglionic eminence

molar

calvaria

triceps brachii muscle

temporal muscle

ankle

intercostal muscle

major salivary gland

More reference expression data

n/a

Gene ontology
Molecular function	transmembrane transporter binding potassium ion binding voltage-gated ion channel activity ankyrin binding voltage-gated potassium channel activity ATP-activated inward rectifier potassium channel activity inward rectifier potassium channel activity ATP binding protein binding protein C-terminus binding heat shock protein binding
Cellular component	integral component of membrane cytosol endosome nuclear envelope membrane intracellular membrane-bounded organelle intercalated disc cell body fiber T-tubule myelin sheath plasma membrane integral component of plasma membrane soma endoplasmic reticulum mitochondrion axolemma inward rectifying potassium channel sarcolemma acrosomal vesicle
Biological process	positive regulation of cation channel activity response to ATP response to estradiol negative regulation of insulin secretion regulation of insulin secretion response to testosterone regulation of membrane potential cellular response to tumor necrosis factor regulation of ion transmembrane transport nervous system process cellular response to nicotine ion transport potassium ion transport response to ischemia potassium ion transmembrane transport glucose metabolic process cellular response to glucose stimulus positive regulation of protein localization to plasma membrane potassium ion import across plasma membrane transmembrane transport regulation of cardiac conduction
Sources:Amigo / QuickGO

Species

Human

Mouse


3767


16514


ENSG00000187486


ENSMUSG00000096146


Q14654


Q61743

RefSeq (mRNA)


NM_000525 NM_001166290 NM_001377296 NM_001377297


NM_001204411 NM_010602

RefSeq (protein)


NP_000516 NP_001159762 NP_001364225 NP_001364226


NP_001191340 NP_034732

Location (UCSC)

Chr 11: 17.37 – 17.39 Mb

Chr 7: 45.74 – 45.75 Mb

PubMed search

View/Edit Human

View/Edit Mouse

K_ir6.2 is a major subunit of the ATP-sensitive K⁺ channel, a lipid-gated inward-rectifier potassium ion channel. The gene encoding the channel is called KCNJ11 and mutations in this gene are associated with congenital hyperinsulinism.