UTX (gene)

KDM6A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3AVR, 3AVS
Identifiers
Aliases	KDM6A, KABUK2, UTX, bA386N14.2, lysine demethylase 6A
External IDs	OMIM: 300128; MGI: 1095419; HomoloGene: 7586; GeneCards: KDM6A; OMA:KDM6A - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	45,112,779 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	18,146,175 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; bone marrow cells; ; left ovary; ; monocyte; ; skin of abdomen; ; germinal epithelium; ; ectocervix; ; vagina; ; epithelium of colon; ; skin of leg;
	Top expressed in
	zygote; ; secondary oocyte; ; genital tubercle; ; primary oocyte; ; internal carotid artery; ; tail of embryo; ; lacrimal gland; ; Rostral migratory stream; ; maxillary prominence; ; external carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	dioxygenase activity; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; identical protein binding; oxidoreductase activity; chromatin DNA binding; histone H3-tri/di-methyl-lysine-27 demethylase activity; histone demethylase activity; chromatin binding; sequence-specific DNA binding;
Cellular component	nucleoplasm; MLL3/4 complex; histone methyltransferase complex; nucleus;
Biological process	respiratory system process; histone H3-K27 demethylation; multicellular organism growth; embryonic organ development; somite rostral/caudal axis specification; heart morphogenesis; in utero embryonic development; heart development; histone H3-K4 methylation; neural tube closure; positive regulation of gene expression; notochord morphogenesis; neural tube development; mesodermal cell differentiation; canonical Wnt signaling pathway; regulation of gene expression; chromatin remodeling; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	7403
	22289
	ENSG00000147050
	ENSMUSG00000037369
	O15550
	O70546
NM_001291415; NM_001291416; NM_001291417; NM_001291418; NM_001291421;
	NM_021140
	NM_009483; NM_001310444
NP_001278344; NP_001278345; NP_001278346; NP_001278347; NP_001278350;
	NP_066963
NP_001297373; NP_033509; NP_001390300; NP_001390301; NP_001390302;
	NP_001390303; NP_001390304; NP_001390305; NP_001390306; NP_001390307; NP_001390308; NP_001390309; NP_001390310
	Wikidata
View/Edit Human	View/Edit Mouse

Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene. It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily.

The Y-chromosome version of this gene is called UTY.