KIF3B

KIF3B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3B6U
Identifiers
Aliases	KIF3B, FLA8, HH0048, KLP-11, kinesin family member 3B, RP89
External IDs	OMIM: 603754; MGI: 107688; HomoloGene: 55849; GeneCards: KIF3B; OMA:KIF3B - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	32,335,011 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	153,175,310 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; islet of Langerhans; ; sperm; ; bronchial epithelial cell; ; renal medulla; ; jejunal mucosa; ; secondary oocyte; ; Brodmann area 23; ; parietal lobe; ; superior frontal gyrus;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; granulocyte; ; neural layer of retina; ; lumbar spinal ganglion; ; dentate gyrus of hippocampal formation granule cell; ; retinal pigment epithelium; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; microtubule binding; protein binding; plus-end-directed microtubule motor activity; ATP binding; microtubule motor activity; ATPase activity; intraciliary transport particle B binding;
Cellular component	cytoplasm; intraciliary transport particle; cytosol; membrane; microtubule cytoskeleton; spindle; plus-end kinesin complex; midbody; ciliary tip; spindle microtubule; extracellular exosome; cytoskeleton; microtubule; axon cytoplasm; centrosome; kinesin II complex; cell projection; axon; cilium; kinesin complex;
Biological process	plus-end-directed vesicle transport along microtubule; antigen processing and presentation of exogenous peptide antigen via MHC class II; mitotic spindle organization; anterograde axonal transport; positive regulation of cytokinesis; mitotic spindle assembly; determination of left/right symmetry; mitotic centrosome separation; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; microtubule-based movement; intraciliary transport involved in cilium assembly;
	Sources:Amigo / QuickGO
Orthologs
	9371
	16569
	ENSG00000101350
	ENSMUSG00000027475
	O15066
	Q61771
	NM_004798
	NM_008444
	NP_004789
	NP_032470
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene. KIF3B is an N-type protein that complexes with two other kinesin proteins to form two-headed anterograde motors. First, KIF3B forms a heterodimer with KIF3A (kinesin-like protein KIF3A); (KIF3A/3B), that is membrane-bound and has ATPase activity. Then KIFAP3 (KAP3, kinesin superfamily associated protein–3) binds to the tail domain to form a heterotrimeric motor. This motor has a plus end-directed microtubule sliding activity that exhibits a velocity of ~0.3 μm/s a. There are 14 kinesin protein families in the kinesin superfamily and KIF3B is part of the Kinesin-2 family, of kinesins that can all form heterotrimeric complexes. Expression of the three motor subunits is ubiquitous. The KIG3A/3B/KAP3 motors can transport 90 to 160 nm in diameter organelles.

There are many orthologous KIF3B genes that are expressed in Drosophila, the sea urchin, Bos taurus, Canis familiaris, Equus caballus, Felis catus, Macaca mulatta, Mus musculus, Pan troglodytes, and Rattus norvegicus.