Kinesin-associated protein 3

KIFAP3
Identifiers
Aliases	KIFAP3, FLA3, KAP-1, KAP-3, KAP3, SMAP, Smg-GDS, dJ190I16.1, kinesin associated protein 3
External IDs	OMIM: 601836; MGI: 107566; HomoloGene: 7799; GeneCards: KIFAP3; OMA:KIFAP3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	170,085,208 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	163,744,678 bp
RNA expression pattern
	Top expressed in
	Pons; ; orbitofrontal cortex; ; lateral nuclear group of thalamus; ; Brodmann area 46; ; frontal pole; ; postcentral gyrus; ; prefrontal cortex; ; ganglionic eminence; ; sperm; ; dorsolateral prefrontal cortex;
	Top expressed in
	barrel cortex; ; facial motor nucleus; ; nucleus accumbens; ; prefrontal cortex; ; subiculum; ; pontine nuclei; ; temporal lobe; ; medial dorsal nucleus; ; anterior horn of spinal cord; ; superior colliculus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; kinesin binding; intraciliary transport particle B binding; protein phosphatase binding;
Cellular component	intraciliary transport particle; ciliary basal body; cytosol; centrosome; Golgi apparatus; kinesin complex; microtubule cytoskeleton; kinesin II complex; photoreceptor connecting cilium; condensed nuclear chromosome; ciliary tip; spindle microtubule; endoplasmic reticulum; periciliary membrane compartment; axoneme; cilium;
Biological process	protein localization; plus-end-directed vesicle transport along microtubule; antigen processing and presentation of exogenous peptide antigen via MHC class II; negative regulation of apoptotic process; microtubule-based movement; positive regulation of calcium-dependent cell-cell adhesion; microtubule-based process; signal transduction; negative regulation of cell population proliferation; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; intraciliary transport involved in cilium assembly; protein-containing complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	22920
	16579
	ENSG00000075945
	ENSMUSG00000026585
	Q92845
	P70188
NM_001204514; NM_001204516; NM_001204517; NM_014970; NM_001375830;
	NM_001375831
	NM_010629; NM_001305643
NP_001191443; NP_001191445; NP_001191446; NP_055785; NP_001362759;
	NP_001362760
	NP_001292572; NP_034759
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin-associated protein 3 (KAP3) is a protein that in humans is encoded by the KIFAP3 gene. It is a non-motor, accessory subunit which co-oligomerizes with the motor subunits KIF3A and KIF3B or KIF3C, to form heterotrimeric kinesin-2 motor proteins. Kinesin-2 KAP subunits were initially characterized in echinoderms and mice.