KMT5B

KMT5B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3S8P
Identifiers
Aliases	KMT5B, CGI85, CGI-85, SUV420H1, lysine methyltransferase 5B, MRD51
External IDs	OMIM: 610881; MGI: 2444557; HomoloGene: 32351; GeneCards: KMT5B; OMA:KMT5B - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	68,213,828 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	3,818,303 bp
RNA expression pattern
	Top expressed in
	mucosa of paranasal sinus; ; visceral pleura; ; caput epididymis; ; sperm; ; pylorus; ; ganglionic eminence; ; cardia; ; ventricular zone; ; parietal pleura; ; superior surface of tongue;
	Top expressed in
	tail of embryo; ; genital tubercle; ; neural layer of retina; ; granulocyte; ; interventricular septum; ; ganglionic eminence; ; ventricular zone; ; Rostral migratory stream; ; superior cervical ganglion; ; thymus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	methyltransferase activity; transferase activity; histone methyltransferase activity (H4-K20 specific); histone-lysine N-methyltransferase activity; protein binding;
Cellular component	chromosome; nucleus; nucleoplasm;
Biological process	histone H4-K20 trimethylation; muscle organ development; histone methylation; methylation; regulation of transcription, DNA-templated; transcription, DNA-templated; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	51111
	225888
	ENSG00000110066
	ENSMUSG00000045098
	Q4FZB7
	Q3U8K7
NM_001300907; NM_001300908; NM_001300909; NM_016028; NM_017635;
	NM_001363566
NM_001167884; NM_001167885; NM_001167886; NM_001167887; NM_001167888;
	NM_001167889; NM_144871; NM_001379678; NM_001379679; NM_001379680
NP_001287836; NP_001287837; NP_001287838; NP_057112; NP_060105;
	NP_001350495; NP_001356353; NP_001356354; NP_001356355; NP_001356356; NP_001356357; NP_001356358; NP_001356359; NP_001356360; NP_001356361; NP_001356362
NP_001161356; NP_001161357; NP_001161358; NP_001161359; NP_001161360;
	NP_001161361; NP_659120; NP_001366607; NP_001366608; NP_001366609
	Wikidata
View/Edit Human	View/Edit Mouse

Histone-lysine N-methyltransferase KMT5B is an enzyme that in humans is encoded by the KMT5B gene. The enzyme along with NSD2 is responsible for dimethylation of lysine 20 on histone H4 in mouse and humans.

This gene encodes a protein that contains a SET domain. SET domains appear to be protein-protein interaction domains that mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). Two alternatively spliced transcript variants have been found for this gene.