Insulin regulated aminopeptidase

LNPEP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PJ6, 4P8Q, 4Z7I, 5C97
Identifiers
Aliases	LNPEP, CAP, IRAP, P-LAP, PLAP, leucyl/cystinyl aminopeptidase, leucyl and cystinyl aminopeptidase
External IDs	OMIM: 151300; MGI: 2387123; HomoloGene: 21148; GeneCards: LNPEP; OMA:LNPEP - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	97,037,513 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	17,845,312 bp
RNA expression pattern
	Top expressed in
	visceral pleura; ; Brodmann area 23; ; tibia; ; parietal pleura; ; epithelium of nasopharynx; ; superficial temporal artery; ; saphenous vein; ; germinal epithelium; ; middle temporal gyrus; ; trabecular bone;
	Top expressed in
	ascending aorta; ; aortic valve; ; superior cervical ganglion; ; hand; ; ciliary body; ; mesenteric lymph nodes; ; otolith organ; ; utricle; ; stroma of bone marrow; ; skin of external ear;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptide binding; metal ion binding; peptidase activity; protein binding; aminopeptidase activity; metallopeptidase activity; metalloaminopeptidase activity; hydrolase activity; zinc ion binding;
Cellular component	integral component of membrane; cytosol; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; extracellular region; lysosomal membrane; perinuclear region of cytoplasm; early endosome lumen; cytoplasmic vesicle membrane;
Biological process	SMAD protein signal transduction; female pregnancy; cell-cell signaling; protein polyubiquitination; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; proteolysis; regulation of blood pressure; protein catabolic process; membrane organization; signal transduction; peptide catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	4012
	240028
	ENSG00000113441
	ENSMUSG00000023845
	Q9UIQ6
	Q8C129
	NM_175920; NM_005575
	NM_172827
	NP_005566; NP_787116
	NP_766415
	Wikidata
View/Edit Human	View/Edit Mouse

Insulin regulated aminopeptidase (IRAP) is a protein that in humans is encoded by the leucyl and cystinyl aminopeptidase (LNPEP) gene. IRAP is a type II transmembrane protein which belongs to the oxytocinase subfamily of M1 aminopeptidases, alongside ERAP1 and ERAP2. It is also known as oxytocinase, leucyl and cystinyl aminopeptidase, placental leucine aminopeptidase (P-LAP), cystinyl aminopeptidase (CAP), and vasopressinase. IRAP is expressed in different cell types, mainly located in specialized regulated endosomes that can be recruited to the cell surface upon cell type-specific receptor activation.