Levocabastine

Levocabastine
	Above: levocabastine molecular structure Below: 3D representation of levocabastine molecule
Clinical data
Trade names	Livostin
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy; category	AU: B3;
Routes of; administration	Ophthalmic, intranasal
ATC code	R01AC02 (WHO) S01GX02 (WHO);
Legal status
Legal status	US: ℞-only; In general: ℞ (Prescription only);
Identifiers
	IUPAC name (3S,4R)-1-[cis-4-cyano-4-(4-fluorophenyl)cyclohexyl]-3-methyl-4-phenyl-4-piperidinecarboxylic acid;
CAS Number	79516-68-0 ;
PubChem CID	54385;
IUPHAR/BPS	1586;
DrugBank	DB01106 ;
ChemSpider	16736421 ;
UNII	H68BP06S81;
KEGG	D08117 ;
ChEMBL	ChEMBL1201312 ;
CompTox Dashboard (EPA)	DTXSID1048548 ;
Chemical and physical data
Formula	C26H29FN2O2
Molar mass	420.528 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc1ccc(cc1)[C@]2(CC[C@@H](CC2)N3CC[C@@]([C@H](C)C3)(c4ccccc4)C(O)=O)C#N;
	InChI InChI=1S/C26H29FN2O2/c1-19-17-29(16-15-26(19,24(30)31)21-5-3-2-4-6-21)23-11-13-25(18-28,14-12-23)20-7-9-22(27)10-8-20/h2-10,19,23H,11-17H2,1H3,(H,30,31)/t19-,23-,25-,26-/m1/s1 ; Key:ZCGOMHNNNFPNMX-KYTRFIICSA-N ;
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Levocabastine (trade name Livostin or Livocab, depending on the region) is a selective second-generation H₁ receptor antagonist which was discovered at Janssen Pharmaceutica in 1979. It is used for allergic conjunctivitis.

As well as acting as an antihistamine, levocabastine has also subsequently been found to act as a potent and selective antagonist for the neurotensin receptor NTS₂, and was the first drug used to characterise the different neurotensin subtypes. This has made it a useful tool for the study of this receptor.

The pharmaceutical drug Bilina is a combination of Levocabastine, benzalkonium chloride, and other components and is typically used in a 0.5 mg/ml suspension as eye-drops, dispensed in 4ml bottles for the treatment of allergic conjunctivitis or similar allergic ocular conditions. Another formulation is available as a nasal spray for the management of allergic rhinitis.