MAGEL2

MAGEL2
Identifiers
Aliases	MAGEL2, NDNL1, PWLS, nM15, SHFYNG, MAGE family member L2
External IDs	OMIM: 605283; MGI: 1351648; HomoloGene: 8460; GeneCards: MAGEL2; OMA:MAGEL2 - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	23,647,867 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	62,031,388 bp
RNA expression pattern
	Top expressed in
	gonad; ; testicle; ; Hypothalamus; ; Brodmann area 23; ; middle temporal gyrus; ; tibia; ; pituitary gland; ; anterior pituitary; ; islet of Langerhans; ; nucleus accumbens;
	Top expressed in
	arcuate nucleus; ; median eminence; ; ventromedial nucleus; ; suprachiasmatic nucleus; ; dorsomedial hypothalamic nucleus; ; paraventricular nucleus of hypothalamus; ; supraoptic nucleus; ; nucleus of stria terminalis; ; labioscrotal swelling; ; tongue;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; ubiquitin-protein transferase activity;
Cellular component	cytoplasm; retromer complex; endosome; early endosome; nucleus; cytosol;
Biological process	protein K63-linked ubiquitination; retrograde transport, endosome to Golgi; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; regulation of circadian rhythm; transcription, DNA-templated; positive regulation of actin nucleation; rhythmic process; Arp2/3 complex-mediated actin nucleation;
	Sources:Amigo / QuickGO
Orthologs
	54551
	27385
	ENSG00000254585
	ENSMUSG00000056972
	Q9UJ55
	Q9QZ04
	NM_019066
	NM_013779
	NP_061939
	NP_038807
	Wikidata
View/Edit Human	View/Edit Mouse

MAGE family member L2 (MAGEL2) is a protein that in human is encoded by the MAGEL2 gene. This protein is a ubuquitin ligase enhancer which is necessary for endsomal protein recycling. This protein is a part of MUST complex (which consists of MAGEL2-USP7-TRIM27 complex).