MAP2K7

MAP2K7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DYL, 3WZU, 4UX9, 5B2K, 5B2L, 5B2M
Identifiers
Aliases	MAP2K7, JNKK2, MAPKK7, MEK, MEK 7, MKK7, PRKMK7, SAPKK-4, SAPKK4, mitogen-activated protein kinase kinase 7
External IDs	OMIM: 603014; MGI: 1346871; HomoloGene: 56548; GeneCards: MAP2K7; OMA:MAP2K7 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	7,914,478 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	4,297,897 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; tendon of biceps brachii; ; gastrocnemius muscle; ; right hemisphere of cerebellum; ; Skeletal muscle tissue of rectus abdominis; ; nipple; ; muscle of thigh; ; cardia; ; body of tongue; ; body of uterus;
	Top expressed in
	external carotid artery; ; internal carotid artery; ; median eminence; ; Gonadal ridge; ; habenula; ; arcuate nucleus; ; lateral geniculate nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	metal ion binding; nucleotide binding; protein tyrosine kinase activity; protein kinase binding; protein kinase activity; magnesium ion binding; transferase activity; kinase activity; ATP binding; enzyme binding; protein phosphatase binding; protein binding; MAP kinase kinase activity; protein serine/threonine kinase activity; JUN kinase kinase activity;
Cellular component	nucleus; cytoplasm; cytosol;
Biological process	response to UV; signal transduction; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; positive regulation of telomere capping; apoptotic process; response to osmotic stress; peptidyl-tyrosine phosphorylation; response to tumor necrosis factor; protein phosphorylation; response to heat; phosphorylation; stress-activated MAPK cascade; regulation of mitotic cell cycle; regulation of apoptotic process; stress-activated protein kinase signaling cascade; activation of protein kinase activity; positive regulation of transcription, DNA-templated; positive regulation of ERK1 and ERK2 cascade; JNK cascade; Fc-epsilon receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	5609
	26400
	ENSG00000076984
	ENSMUSG00000002948
	O14733
	Q8CE90
	NM_001297555; NM_001297556; NM_145185
NM_001042557; NM_001164172; NM_001291777; NM_001291778; NM_001291783;
	NM_011944
	NP_001284484; NP_001284485; NP_660186
NP_001036022; NP_001157644; NP_001278706; NP_001278707; NP_001278712;
	NP_036074
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity mitogen-activated protein kinase kinase 7, also known as MAP kinase kinase 7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7 gene. This protein is a member of the mitogen-activated protein kinase kinase family. The MKK7 protein exists as six different isoforms with three possible N-termini (α, β, and γ isoforms) and two possible C-termini (1 and 2 isoforms).

MKK7 is involved in signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK.

MKK7 is ubiquitously expressed in all tissue. However, it displays a higher level of expression in skeletal muscle. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found.