MB-3 (drug)

MB-3 (drug)
Identifiers
  • (2R,3S)-4-methylidene-5-oxo-2-propyloxolane-3-carboxylic acid
CAS Number
PubChem CID
ChemSpider
ChEBI
ChEMBL
Chemical and physical data
FormulaC9H12O4
Molar mass184.191 g·mol−1
3D model (JSmol)
  • CCC[C@@H]1[C@H](C(=C)C(=O)O1)C(=O)O
  • InChI=1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1
  • Key:SRQUTZJZABSZRQ-RQJHMYQMSA-N

MB-3 is a drug which acts as a potent and selective inhibitor of the histone acetyltransferase enzyme GCN5, which usually functions as a negative modulator of PGC-1α, and so MB-3 acts to indirectly activate PGC-1α. It is used in research into the role of the GCN5/PGC-1α pathway in the regulation of metabolism and cell differentiation.

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