Midkine

MDK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MKC, 1MKN
Identifiers
Aliases	MDK, ARAP, MK, NEGF2, midkine (neurite growth-promoting factor 2), midkine
External IDs	OMIM: 162096; MGI: 96949; HomoloGene: 1792; GeneCards: MDK; OMA:MDK - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	46,383,837 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	91,762,642 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; stromal cell of endometrium; ; pituitary gland; ; left ovary; ; canal of the cervix; ; anterior pituitary; ; right uterine tube; ; ganglionic eminence; ; duodenum; ; right ovary;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ventricular zone; ; yolk sac; ; epiblast; ; ganglionic eminence; ; uterus; ; neural tube; ; embryo; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	growth factor activity; heparin binding;
Cellular component	cytoplasm; cell projection; extracellular region; collagen-containing extracellular matrix;
Biological process	Notch signaling pathway; negative regulation of neuron apoptotic process; regulation of behavior; cerebellar granular layer development; dentate gyrus development; response to glucocorticoid; behavioral fear response; nervous system development; positive regulation of transcription, DNA-templated; multicellular organism development; defecation; short-term memory; cerebral cortex development; response to hormone; cell migration; hippocampus development; positive regulation of cell division; signal transduction; negative regulation of neuron death; response to wounding; adrenal gland development; cell differentiation; regulation of signaling receptor activity;
	Sources:Amigo / QuickGO
Orthologs
	4192
	17242
	ENSG00000110492
	ENSMUSG00000027239
	P21741
	P12025
NM_001012333; NM_001012334; NM_001270550; NM_001270551; NM_001270552;
	NM_002391
NM_001012335; NM_001012336; NM_010784; NM_001291481; NM_001291482;
	NM_001291483
NP_001012333; NP_001012334; NP_001257479; NP_001257480; NP_001257481;
	NP_002382
NP_001012335; NP_001012336; NP_001278410; NP_001278411; NP_001278412;
	NP_034914
	Wikidata
View/Edit Human	View/Edit Mouse

Midkine (MK or MDK), also known as neurite growth-promoting factor 2 (NEGF2), is a protein that in humans is encoded by the MDK gene.

Midkine is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin (NEGF1, 46% homologous with MK). It is a nonglycosylated protein, composed of two domains held by disulfide bridges. It is a developmentally important retinoic acid-responsive gene product strongly induced during mid-gestation, hence the name midkine. Restricted mainly to certain tissues in the normal adult, it is strongly induced during oncogenesis, inflammation and tissue repair.

MK is pleiotropic, capable of exerting activities such as cell proliferation, cell migration, angiogenesis and fibrinolysis. A molecular complex containing receptor-type tyrosine phosphatase zeta (PTPζ), low density lipoprotein receptor-related protein (LRP1), anaplastic leukemia kinase (ALK) and syndecans is considered to be its receptor.