MFAP5

MFAP5
Identifiers
Aliases	MFAP5, MAGP-2, MAGP2, MFAP-5, MP25, AAT9, microfibrillar associated protein 5, microfibril associated protein 5
External IDs	OMIM: 601103; MGI: 1354387; HomoloGene: 2599; GeneCards: MFAP5; OMA:MFAP5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	8,662,888 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	122,506,249 bp
RNA expression pattern
	Top expressed in
	synovial joint; ; skin of hip; ; tibial nerve; ; smooth muscle tissue; ; pericardium; ; placenta; ; right coronary artery; ; vena cava; ; urethra; ; decidua;
	Top expressed in
	decidua; ; gastrula; ; ascending aorta; ; sciatic nerve; ; aortic valve; ; cervix; ; ankle; ; esophagus; ; intercostal muscle; ; extraocular muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	extracellular matrix structural constituent;
Cellular component	extracellular region; microfibril; extracellular matrix; collagen-containing extracellular matrix;
Biological process	definitive hemopoiesis; extracellular matrix organization; supramolecular fiber organization;
	Sources:Amigo / QuickGO
Orthologs
	8076
	50530
	ENSG00000197614
	ENSMUSG00000030116
	Q13361
	Q9QZJ6
	NM_001297709; NM_001297710; NM_001297711; NM_001297712; NM_003480
	NM_015776; NM_001347434
	NP_001284638; NP_001284639; NP_001284640; NP_001284641; NP_003471
	NP_001334363; NP_056591
	Wikidata
View/Edit Human	View/Edit Mouse

Microfibrillar-associated protein 5 is a protein that in humans is encoded by the MFAP5 gene.

This gene encodes a 25-kD microfibril-associated glycoprotein which is rich in serine and threonine residues. It lacks a hydrophobic carboxyl terminus and proline-, glutamine-, and tyrosine-rich regions, which are characteristics of a related 31-kDa microfibril-associated glycoprotein (MFAP2). The close similarity between these two proteins is confined to a central region of 60 aa where precise alignment of 7 cysteine residues occurs. The structural differences suggest that this encoded protein has some functions that are distinct from those of MFAP2.