MFN2

MFN2
Identifiers
Aliases	MFN2, CMT2A, CMT2A2, CPRP1, HSG, MARF, HMSN6A, mitofusin 2, CMT2A2A, CMT2A2B
External IDs	OMIM: 608507; MGI: 2442230; HomoloGene: 8915; GeneCards: MFN2; OMA:MFN2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	12,015,211 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	147,989,161 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; left ventricle; ; muscle of thigh; ; right auricle of heart; ; gastrocnemius muscle; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; optic nerve; ; Skeletal muscle tissue of rectus abdominis; ; thoracic diaphragm;
	Top expressed in
	interventricular septum; ; myocardium of ventricle; ; digastric muscle; ; muscle of thigh; ; skeletal muscle tissue; ; temporal muscle; ; quadriceps femoris muscle; ; soleus muscle; ; vastus lateralis muscle; ; right ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; hydrolase activity; ubiquitin protein ligase binding; GTPase activity;
Cellular component	cytosol; membrane; microtubule cytoskeleton; mitochondrial outer membrane; mitochondrion; integral component of membrane; intrinsic component of mitochondrial outer membrane;
Biological process	mitochondrial fusion; negative regulation of smooth muscle cell proliferation; protein localization to phagophore assembly site; mitochondrion localization; protein targeting to mitochondrion; blood coagulation; blastocyst formation; negative regulation of Ras protein signal transduction; autophagy; response to unfolded protein; macroautophagy; mitochondrial membrane organization; camera-type eye morphogenesis; apoptotic process; parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	9927
	170731
	ENSG00000116688
	ENSMUSG00000029020
	O95140
	Q80U63
	NM_001127660; NM_014874
NM_001285920; NM_001285921; NM_001285922; NM_001285923; NM_133201;
	NM_001355590; NM_001355591
	NP_001121132; NP_055689
NP_001272849; NP_001272850; NP_001272851; NP_001272852; NP_573464;
	NP_001342519; NP_001342520
	Wikidata
View/Edit Human	View/Edit Mouse

Mitofusin-2 is a protein that in humans is encoded by the MFN2 gene. Mitofusins are GTPases embedded in the outer membrane of the mitochondria. In mammals MFN1 and MFN2 are essential for mitochondrial fusion. In addition to the mitofusins, OPA1 regulates inner mitochondrial membrane fusion, and DRP1 is responsible for mitochondrial fission.

Mitofusin-2 (MFN2) is a mitochondrial membrane protein that plays a central role in regulating mitochondrial fusion and cell metabolism. More specifically, MFN2 is a dynamin-like GTPase embedded in the outer mitochondrial membrane (OMM) which in turn affects mitochondrial dynamics, distribution, quality control, and function.

In addition to the MFN2, OPA1 regulates inner mitochondrial membrane fusion, MFN1 is a mediator of mitochondrial fusion and DRP1 is responsible for mitochondrial fission.