MK-886

MK-886
Names
	Preferred IUPAC name 3-{3-(tert-Butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl}-2,2-dimethylpropanoic acid
	Other names L-663536
Identifiers
CAS Number	118414-82-7 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:75390;
ChEMBL	ChEMBL29097;
ChemSpider	2885052;
DrugBank	DB16739;
MeSH	L+663536
PubChem CID	3651377;
UNII	080626SQ8C ;
CompTox Dashboard (EPA)	DTXSID5041067 ;
	InChI InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31) Key: QAOAOVKBIIKRNL-UHFFFAOYSA-N;
	SMILES CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl;
Properties
Chemical formula	C27H34ClNO2S
Molar mass	472.083
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

MK-886, or L-663536, is a leukotriene antagonist. It may perform this by blocking the 5-lipoxygenase activating protein (FLAP), thus inhibiting 5-lipoxygenase (5-LOX), and may help in treating atherosclerosis.

MK-886 is a synthesized chemical compound known for its role in inhibiting the 5-lipoxygenase-activating protein (FLAP). Key part in leukotriene biosynthesis. It has potential therapeutic applications in different types of cancer when paired up with other synthetically made chemical compounds. This includes the cancer cells doing apoptosis and suppress tumor cell growth independent from leukotriene inhibition with some cases.

Names

Preferred IUPAC name 3-{3-(tert-Butylsulfanyl)-1-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1H-indol-2-yl}-2,2-dimethylpropanoic acid
Other names L-663536
Identifiers
CAS Number	118414-82-7^Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:75390
ChEMBL	ChEMBL29097
ChemSpider	2885052
DrugBank	DB16739
MeSH	L+663536
PubChem CID	3651377
UNII	080626SQ8C^Y
CompTox Dashboard (EPA)	DTXSID5041067
InChI InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31) Key: QAOAOVKBIIKRNL-UHFFFAOYSA-N
SMILES CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl
Properties
Chemical formula	C₂₇H₃₄ClNO₂S
Molar mass	472.083
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Y verify (what is ^YN ?) Infobox references