MSH3

MSH3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3THW, 3THX, 3THY, 3THZ
Identifiers
Aliases	MSH3, DUP, MRP1, mutS homolog 3, FAP4
External IDs	OMIM: 600887; MGI: 109519; HomoloGene: 1829; GeneCards: MSH3; OMA:MSH3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	80,876,815 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	92,491,511 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; mucosa of paranasal sinus; ; secondary oocyte; ; cardia; ; gonad; ; testicle; ; renal medulla; ; external globus pallidus; ; subthalamic nucleus; ; Achilles tendon;
	Top expressed in
	zygote; ; tail of embryo; ; spermatocyte; ; secondary oocyte; ; genital tubercle; ; primary oocyte; ; ventricular zone; ; epiblast; ; spermatid; ; neural layer of retina;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; DNA binding; protein homodimerization activity; mismatched DNA binding; dinucleotide insertion or deletion binding; oxidized purine DNA binding; single-stranded DNA binding; protein binding; enzyme binding; dinucleotide repeat insertion binding; ATP binding; single guanine insertion binding; guanine/thymine mispair binding; Y-form DNA binding; heteroduplex DNA loop binding; double-strand/single-strand DNA junction binding; damaged DNA binding; ATP-dependent activity, acting on DNA; single thymine insertion binding; DNA insertion or deletion binding;
Cellular component	MutSbeta complex; membrane; nucleoplasm; nucleus; mismatch repair complex;
Biological process	cellular response to DNA damage stimulus; maintenance of DNA repeat elements; positive regulation of helicase activity; negative regulation of DNA recombination; DNA mismatch repair; DNA repair; somatic recombination of immunoglobulin gene segments; meiotic mismatch repair; removal of nonhomologous ends; mitotic recombination; reciprocal meiotic recombination; replication fork arrest;
	Sources:Amigo / QuickGO
Orthologs
	4437
	17686
	ENSG00000113318
	ENSMUSG00000014850
	P20585
	P13705
	NM_002439
	NM_010829; NM_001311120
	NP_002430
	NP_001298049; NP_034959
	Wikidata
View/Edit Human	View/Edit Mouse

DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs in microsatellites during DNA synthesis. Deficient capacity for MMR is found in approximately 15% of colorectal cancers, and somatic mutations in the MSH3 gene can be found in nearly 50% of MMR-deficient colorectal cancers.