Moesin

MSN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1E5W, 1EF1, 1SGH
Identifiers
Aliases	MSN, HEL70, moesin, IMD50
External IDs	OMIM: 309845; MGI: 97167; HomoloGene: 1833; GeneCards: MSN; OMA:MSN - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	65,741,931 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	95,212,158 bp
RNA expression pattern
	Top expressed in
	lower lobe of lung; ; white blood cell; ; monocyte; ; granulocyte; ; synovial joint; ; saphenous vein; ; synovial membrane; ; right lung; ; appendix; ; smooth muscle tissue;
	Top expressed in
	right lung; ; right lung lobe; ; left lung; ; endothelial cell of lymphatic vessel; ; left lung lobe; ; granulocyte; ; mesenteric lymph nodes; ; stroma of bone marrow; ; ascending aorta; ; tibiofemoral joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytoskeletal protein binding; structural constituent of cytoskeleton; protein binding; actin binding; double-stranded RNA binding; signaling receptor binding; protein kinase binding; cell adhesion molecule binding; enzyme binding;
Cellular component	cytoplasm; vesicle; cell projection; pseudopodium; blood microparticle; membrane; focal adhesion; filopodium; myelin sheath; plasma membrane; apical part of cell; microvillus; uropod; basolateral plasma membrane; apical plasma membrane; perinuclear region of cytoplasm; extracellular exosome; cytoskeleton; microvillus membrane; nucleus; cell periphery; extracellular space; cell surface; cytosol;
Biological process	leukocyte cell-cell adhesion; regulation of cell size; establishment of endothelial barrier; regulation of organelle assembly; cellular response to testosterone stimulus; regulation of lymphocyte migration; positive regulation of podosome assembly; gland morphogenesis; positive regulation of gene expression; establishment of epithelial cell apical/basal polarity; regulation of cell shape; membrane to membrane docking; positive regulation of protein localization to early endosome; positive regulation of early endosome to late endosome transport; leukocyte migration; cytoskeleton organization; immunological synapse formation; T cell proliferation; T cell aggregation; T cell migration; interleukin-12-mediated signaling pathway; viral process;
	Sources:Amigo / QuickGO
Orthologs
	4478
	17698
	ENSG00000147065
	ENSMUSG00000031207
	P26038
	P26041
	NM_002444
	NM_010833
	NP_002435
	NP_034963
	Wikidata
View/Edit Human	View/Edit Mouse

Moesin is a protein that in humans is encoded by the MSN gene.

Moesin (for membrane-organizing extension spike protein) is a member of the ERM protein family which includes ezrin and radixin. ERM proteins appear to function as cross-linkers between plasma membranes and actin-based cytoskeletons.

Moesin is localized to filopodia and other membranous protrusions that are important for cell–cell recognition and signaling and for cell movement.

Moesin has FERM domain at N-terminal.