MTA2

MTA2
Identifiers
Aliases	MTA2, MTA1L1, PID, metastasis associated 1 family member 2
External IDs	OMIM: 603947; MGI: 1346340; HomoloGene: 3480; GeneCards: MTA2; OMA:MTA2 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	62,601,865 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	8,929,667 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; ganglionic eminence; ; skin of abdomen; ; skin of leg; ; left uterine tube; ; rectum; ; smooth muscle tissue; ; ventricular zone; ; right ovary; ; tibial nerve;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; thymus; ; genital tubercle; ; tail of embryo; ; lip; ; granulocyte; ; epiblast; ; mesenteric lymph nodes; ; tibiofemoral joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; zinc ion binding; histone deacetylase binding; chromatin binding; metal ion binding; protein binding; nucleosomal DNA binding; histone deacetylase activity; transcription cis-regulatory region binding; DNA-binding transcription factor activity, RNA polymerase II-specific; transcription coregulator activity; transcription coactivator activity; transcription corepressor activity;
Cellular component	histone deacetylase complex; NuRD complex; membrane; transcription regulator complex; nucleoplasm; nucleus; protein-containing complex;
Biological process	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; DNA methylation; regulation of fibroblast migration; negative regulation of transcription, DNA-templated; histone deacetylation; positive regulation of transcription by RNA polymerase II; regulation of signal transduction by p53 class mediator;
	Sources:Amigo / QuickGO
Orthologs
	9219
	23942
	ENSG00000149480
	ENSMUSG00000071646
	O94776
	Q9R190
	NM_004739; NM_001330292
	NM_011842
	NP_001317221; NP_004730
	NP_035972
	Wikidata
View/Edit Human	View/Edit Mouse

Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.

MTA2 is the second member of the MTA family of genes. MTA2 protein localizes in the nucleus and is a component of the nucleosome remodeling and the deacetylation complex (NuRD). Similar to the founding family member MTA1, MTA2 functions as a chromatin remodeling factor and regulates gene expression. MTA2 is overexpressed in human cancer and its dysregulated level correlates well with cancer invasiveness and aggressive phenotypes.