Major vault protein

MVP
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Y7X
Identifiers
Aliases	MVP, LRP, VAULT1, major vault protein, lung resistance-related protein
External IDs	OMIM: 605088; MGI: 1925638; HomoloGene: 3752; GeneCards: MVP; OMA:MVP - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	29,848,039 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,613,793 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; right adrenal gland; ; left adrenal gland; ; left adrenal cortex; ; granulocyte; ; right adrenal cortex; ; epithelium of colon; ; upper lobe of left lung; ; stromal cell of endometrium; ; right ovary;
	Top expressed in
	ankle joint; ; duodenum; ; intestinal villus; ; Ileal epithelium; ; jejunum; ; granulocyte; ; colon; ; yolk sac; ; lip; ; membranous bone;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase binding; protein binding; protein kinase binding; identical protein binding;
Cellular component	cytoplasm; perinuclear region of cytoplasm; nuclear pore; extracellular exosome; cytoskeleton; membrane; nucleus; extracellular region; cytosol; secretory granule lumen; ficolin-1-rich granule lumen;
Biological process	protein transport; mRNA transport; negative regulation of protein tyrosine kinase activity; ERBB signaling pathway; negative regulation of signaling; negative regulation of protein autophosphorylation; neutrophil degranulation; transport;
	Sources:Amigo / QuickGO
Orthologs
	9961
	78388
	ENSG00000013364
	ENSMUSG00000030681
	Q14764
	Q9EQK5
	NM_017458; NM_001293204; NM_001293205; NM_005115
	NM_080638
	NP_001280133; NP_001280134; NP_005106; NP_059447; NP_001280134.1
	NP_542369
	Wikidata
View/Edit Human	View/Edit Mouse

Major vault protein, also known as lung resistance-related protein is a protein that in humans is encoded by the MVP gene. 78 copies of the protein assemble into the large compartments called vaults.