MYF5

MYF5
Identifiers
Aliases	MYF5, bHLHc2, myogenic factor 5, EORVA
External IDs	OMIM: 159990; MGI: 97252; HomoloGene: 4085; GeneCards: MYF5; OMA:MYF5 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	80,719,671 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	107,321,995 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; muscle of thigh; ; gastrocnemius muscle; ; skeletal muscle tissue; ; deltoid muscle; ; tibialis anterior muscle; ; body of tongue; ; exocrine gland; ; salivary gland; ; male reproductive gland;
	Top expressed in
	myotome; ; urethra; ; male urethra; ; human fetus; ; extraocular muscle; ; muscle layer of urethra; ; soleus muscle; ; muscle of upper limb; ; internal carotid artery; ; temporal muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; protein dimerization activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; E-box binding; protein binding; protein heterodimerization activity; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleoplasm; RNA polymerase II transcription regulator complex; nucleus;
Biological process	somitogenesis; embryonic skeletal system morphogenesis; cell differentiation; regulation of transcription, DNA-templated; muscle organ morphogenesis; ossification; positive regulation of muscle cell differentiation; regulation of transcription by RNA polymerase II; muscle cell fate commitment; muscle organ development; extracellular matrix organization; transcription by RNA polymerase II; positive regulation of skeletal muscle fiber development; transcription, DNA-templated; regulation of cell-matrix adhesion; multicellular organism development; positive regulation of myoblast fusion; positive regulation of myoblast differentiation; muscle tissue morphogenesis; skeletal muscle cell differentiation; camera-type eye development; skeletal muscle tissue development; cartilage condensation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	4617
	17877
	ENSG00000111049
	ENSMUSG00000000435
	P13349
	P24699
	NM_005593
	NM_008656
	NP_005584
	NP_032682
	Wikidata
View/Edit Human	View/Edit Mouse

Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix transcription factors act sequentially in myogenic differentiation. MRF family members include Myf5, MyoD (Myf3), myogenin, and MRF4 (Myf6). This transcription factor is the earliest of all MRFs to be expressed in the embryo, where it is only markedly expressed for a few days (specifically around 8 days post-somite formation and lasting until day 14 post-somite in mice). It functions during that time to commit myogenic precursor cells to become skeletal muscle. In fact, its expression in proliferating myoblasts has led to its classification as a determination factor. Furthermore, Myf5 is a master regulator of muscle development, possessing the ability to induce a muscle phenotype upon its forced expression in fibroblastic cells.