MYL2

MYL2
Identifiers
Aliases	MYL2, CMH10, MLC2, MLC-2s/v, myosin light chain 2, MFM12
External IDs	OMIM: 160781; MGI: 97272; HomoloGene: 55462; GeneCards: MYL2; OMA:MYL2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	110,921,443 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	122,113,472 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; apex of heart; ; thoracic diaphragm; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; muscle of thigh; ; tibialis anterior muscle; ; glutes; ; triceps brachii muscle; ; deltoid muscle;
	Top expressed in
	cardiac muscle tissue of left ventricle; ; interventricular septum; ; right ventricle; ; atrioventricular valve; ; soleus muscle; ; plantaris muscle; ; endocardial cushion; ; semi-lunar valve; ; aortic valve; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; actin monomer binding; metal ion binding; myosin heavy chain binding; protein binding; structural constituent of muscle;
Cellular component	cytoplasm; cytosol; sarcomere; myofibril; actin cytoskeleton; A band; cytoskeleton; myosin complex; cardiac myofibril;
Biological process	cardiac muscle contraction; positive regulation of the force of heart contraction; regulation of the force of heart contraction; heart morphogenesis; post-embryonic development; cardiac myofibril assembly; ventricular cardiac muscle tissue morphogenesis; heart development; regulation of striated muscle contraction; negative regulation of cell growth; muscle filament sliding; muscle cell fate specification; heart contraction;
	Sources:Amigo / QuickGO
Orthologs
	4633
	17906
	ENSG00000111245
	ENSMUSG00000013936
	P10916
	P51667
	NM_000432
	NM_010861
	NP_000423
NP_034991; NP_001371255; NP_001371256; NP_001371257; NP_001371258;
	NP_001371259; NP_001371260
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle (MYLPF), smooth muscle (MYL12B) and cardiac atrial muscle (MYL7).

Ventricular myosin light chain-2 (MLC-2v) refers to the ventricular cardiac muscle form of myosin light chain 2 (Myl2). MLC-2v is a 19-KDa protein composed of 166 amino acids, that belongs to the EF-hand Ca²⁺ binding superfamily. MLC-2v interacts with the neck/tail region of the muscle thick filament protein myosin to regulate myosin motility and function.