MYOZ2

MYOZ2
Identifiers
Aliases	MYOZ2, C4orf5, CMH16, CS-1, myozenin 2, FATZ-2
External IDs	OMIM: 605602; MGI: 1913063; HomoloGene: 9583; GeneCards: MYOZ2; OMA:MYOZ2 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	119,187,789 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	122,828,664 bp
RNA expression pattern
	Top expressed in
	right ventricle; ; myocardium of left ventricle; ; cardiac muscle tissue of right atrium; ; thoracic diaphragm; ; glutes; ; vena cava; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; right auricle of heart;
	Top expressed in
	interventricular septum; ; soleus muscle; ; myocardium of ventricle; ; cardiac muscles; ; right ventricle; ; intercostal muscle; ; thoracic diaphragm; ; atrioventricular valve; ; ankle; ; extraocular muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein phosphatase 2B binding; protein binding; telethonin binding; actin binding; FATZ binding;
Cellular component	cytoplasm; sarcomere; actin cytoskeleton; Z discdkac;
Biological process	myofibril assembly; biological process; negative regulation of transcription by RNA polymerase II; skeletal muscle tissue development; skeletal muscle fiber adaptation; sarcomere organization; negative regulation of calcineurin-NFAT signaling cascade;
	Sources:Amigo / QuickGO
Orthologs
	51778
	59006
	ENSG00000172399
	ENSMUSG00000028116
	Q9NPC6
	Q9JJW5
	NM_016599
	NM_021503; NM_001355462
	NP_057683
	NP_067478; NP_001342391
	Wikidata
View/Edit Human	View/Edit Mouse

Myozenin-2, also referred to as Calsarcin-1, is a protein that in humans is encoded by the MYOZ2 gene. The Calsarcin-1 isoform is a muscle protein expressed in cardiac muscle and slow-twitch skeletal muscle, which functions to tether calcineurin to alpha-actinin at Z-discs, and inhibit the pathological cardiac hypertrophic response. This differs from the fast-skeletal muscle isoform, calsarcin-2.