Macrogol

Macrogol is the international nonproprietary name used for polyethylene glycol (PEG) as a medication ingredient. It is usually followed by a number indicating the average molecular weight, indicating the length of the polymer of the specific molecule in use. Macrogol is used as a laxative to treat constipation in children and adults. It is taken by mouth. Benefits usually occur within three days. It is also used as an excipient. It is also used to clear the bowels before a colonoscopy, when the onset of the laxative effect is more rapid, typically within an hour.

Side effects may include increased bowel gas, abdominal pain, and nausea. Rare but serious side effects may include an abnormal heartbeat, seizures, and kidney problems. Use appears to be safe during pregnancy. It is classified as an osmotic laxative: It works by increasing the amount of water in the stool.

Macrogol came into use as a bowel prep in 1980 and was approved for medical use in the United States in 1999. It is available as a generic medication and over the counter. In 2022, it was the 209th most commonly prescribed medication in the United States, with more than 1 million prescriptions. It is also formulated together with electrolytes. In 2022, the combination with electrolytes was the 282nd most commonly prescribed medication in the US, with more than 600,000 prescriptions.